NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について Effects of Methylene Blue on the Relaxation and Increses in CyclicGMP Concentrations of Vascular Smooth Muscle Produced by NO-formingVasodilators and Atriopeptin

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著者

    • 捧, 博輝 ササゲ, ヒロキ

書誌事項

タイトル

NO-forming vasodilatorsとatriopeptinによる血管平滑筋の弛緩とcyclic GMP増加に対するmethylene blueの効果について

タイトル別名

Effects of Methylene Blue on the Relaxation and Increses in CyclicGMP Concentrations of Vascular Smooth Muscle Produced by NO-formingVasodilators and Atriopeptin

著者名

捧, 博輝

著者別名

ササゲ, ヒロキ

学位授与大学

新潟大学

取得学位

医学博士

学位授与番号

甲第855号

学位授与年月日

1992-03-31

注記・抄録

博士論文

学位の種類: 博士(医学). 報告番号: 甲第855号. 学位記番号: 新大院博(医)甲第651号. 学位授与年月日: 平成4年3月31日

新潟医学会雑誌. 1992, 106(7), 631-641.

In the isolated endothelium-removed rabbit aorta (RA) precontracted with phenylephrine, 15 min treatment with methylene blue (15min-MB) resulted in a rightward shift of the dose-response curve (DRC) for nitroglycerin (NTG) and nitric oxide (NO), while DRC for NaN0_2, sodium nitroprusside (SNP) and atriopeptin(ANP) was not affected. DRC for SNP was not affected in the dog coronary artery (DCA) (endothelium-removed and precontracted with KG1), while DRC for SNP was shifted to the right in the rat and guinea pig aorta. The relaxation by SNP or NaNO_2 was attenuated after 60 min-MB in RA but not in DCA. The relaxation by ANP was not affected after 60 min-MB. While increases in tissue cyclic GMP in RA by NTG and NO were attenuated after 15 min-MB, the increases by SNP, NaNO_2 and ANP were not affected even after 60 min-MB. The relaxant effects of 8-Br cyclic GMP were not attenuated after 60min-MB. Thus, the inhibition by MB of relaxation by SNP and NaNO_2 was due to its action on a process or processes operative before and/or in parallel with the accumulation of cyclic GMP. Species differences in the penetrability of MB were suggested.

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各種コード

  • NII論文ID(NAID)
    500000087116
  • NII著者ID(NRID)
    • 8000000087332
  • DOI(NDL)
  • 本文言語コード
    • jpn
  • NDL書誌ID
    • 000000251430
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
    • NDLデジタルコレクション
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