膠原病患者における抗リン脂質抗体の検討 Antiphospholipid antibodies in patients with collagen diseases
Antiphospholipid antibodies in patients with collagen diseases
学位の種類: 博士（医学）. 報告番号: 乙第1204号. 学位記番号: 新大院博（医）乙第1121号. 学位授与年月日: 平成4年1月22日
日本臨床免疫学会会誌. 1992, 15(1), 29-37.
Antiphospholipid antibodies, antibodies to cardiolipin (CL) and to phosphatidyl serine (PS), were measured in the sera of 197 patients with various collagen diseases, including 108 patients with systemic lupus erythematosus (SLE), 29 patients with mixed connective tissue disease (MCTD), 39 patients with rheumatoid arthritis, 13 patients with Sjogren's syndrome and 8 patients with scleroderma. IgG anti-CL antibodies were found in 68 (63%) of SLE, 18 (62.1%) of MCTD, 13 (33.3%) of rheumatoid arthritis, 9 (69.2%) of Sjogren's syndrome, and 2 (25%) of scleroderma. IgG anti-PS antibodies were also found in 39 (36.1%), 15 (51.7%), 10 (25.6%), 9 (69.2%), and 1 (12.5%), respectively. In patients with SLE both antibodies were significantly related to thrombocytopenia, CNS lupus and spontaneous abortion. In patients with MCTD there was a significant association between antiphospholipid antibodies and pulmonary hypertension. In patients with rheumatoid arthritis anti-CL antibody was significantly associated with positive antinuclear antibody, positive anti-SSA antibody and sicca symptom.