Structural studies of a protein protease inhibitor SSI (Streptomyces subtilisin inhibitor) : protease complex by means of NMR spectroscopy 蛋白性プロテアーゼインヒビターSSI プロテアーゼ複合体のNMRによる構造研究
この論文にアクセスする
この論文をさがす
著者
書誌事項
- タイトル
-
Structural studies of a protein protease inhibitor SSI (Streptomyces subtilisin inhibitor) : protease complex by means of NMR spectroscopy
- タイトル別名
-
蛋白性プロテアーゼインヒビターSSI
- タイトル別名
-
プロテアーゼ複合体のNMRによる構造研究
- 著者名
-
三宅, 洋子
- 著者別名
-
ミヤケ, ヨウコ
- 学位授与大学
-
東京都立大学
- 取得学位
-
理学博士
- 学位授与番号
-
甲第284号
- 学位授与年月日
-
1992-03-25
注記・抄録
博士論文
目次
- CONTENTS / (0004.jp2)
- Ackowledgements / (0009.jp2)
- Chapter-1 General Intorduction- Historical Background and the Features of the Present Work / p1 (0010.jp2)
- 1.1 Protein Protease Inhibitor / p2 (0011.jp2)
- 1.2 NMR Spectroscopy for Conformational Study of Protein / p7 (0014.jp2)
- References / p19 (0022.jp2)
- Chapter-1 ¹³C-NMR Study of the Scissile Bond of Streptomyces Subtilisin Inhibitor(SSI) in Complex with Subtilisin BPN' / p22 (0024.jp2)
- Abstruct / p23 (0025.jp2)
- Abbreviations / p24 (0026.jp2)
- 2.1 Introduction / p25 (0026.jp2)
- 2.2 Materials and Methods / p32 (0031.jp2)
- 2.3 Results / p37 (0035.jp2)
- 2.4 Discussion / p51 (0047.jp2)
- References / p66 (0059.jp2)
- Chapter-3 ¹³C-NMR study of Stable Intermediate in Streptomyces Subtilisin Inhibitor (SSI)-Subtilisin BPN' / p69 (0061.jp2)
- Abstruct / p70 (0062.jp2)
- Abbreviations / p71 (0063.jp2)
- 3.1 Introduction / p72 (0063.jp2)
- 3.2 Materials and Methods / p78 (0066.jp2)
- 3.3 Results / p81 (0068.jp2)
- 3.4 Discussion / p87 (0073.jp2)
- References / p91 (0075.jp2)
- Chapter-4 ¹³C-NMR Studies of Comformational Change of SSI,Induced by Complex Formation with Subtilisin BPN' / p94 (0077.jp2)
- Abbreviations / p95 (0078.jp2)
- 4.1 Introducrion / p96 (0079.jp2)
- 4.2 Materials and Methods / p104 (0085.jp2)
- 4.3 Results / p106 (0086.jp2)
- 4.4 Discussion / p141 (0118.jp2)
- References / p157 (0129.jp2)
- Chapter-5 ¹³C-NMR Studies of Conformational Properties of SSI / p159 (0130.jp2)
- Abbreviations / p160 (0131.jp2)
- 5.1 Introduction / p161 (0132.jp2)
- 5.2 Materials and Methods / p164 (0134.jp2)
- 5.3 Results / p167 (0135.jp2)
- 5.4 Discussion / p184 (0150.jp2)
- References / p199 (0160.jp2)
- Chapter-6 Conformational Change of SSI by Complex Formation with Various Target Proteases / p201 (0161.jp2)
- Abbreviations / p202 (0162.jp2)
- 6.1 Introduction / p203 (0163.jp2)
- 6.2 Materials and Methods / p207 (0166.jp2)
- 6.3 Results / p212 (0169.jp2)
- 6.4 Discussion / p241 (0197.jp2)
- References / p251 (0202.jp2)
- Chapter-7 Concluding Remarks / p252 (0203.jp2)
- 7.1 The Conformational Study of SSI-Protease Complex / p253 (0204.jp2)
- 7.2 NMR Spectroscopy of a Large Protein / p257 (0206.jp2)