実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響 実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響

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著者

    • 北, 俊弘 キタ, トシヒロ

書誌事項

タイトル

実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響

タイトル別名

実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響

著者名

北, 俊弘

著者別名

キタ, トシヒロ

学位授与大学

宮崎医科大学

取得学位

博士 (医学)

学位授与番号

甲第87号

学位授与年月日

1991-03-25

注記・抄録

博士論文

Recently rat brain natriuretic peptide-45(rat BNP-45) was isolated from rat heart, and was shown to be a circulating form of rat BNP. We investigated the effects of rat BNP-45 in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), and compared them with those of rat a-atrial natriuretic peptide(a-ANP). BNP-45 was a potent natriuretic and hypotensive agent in both strains. The effects were comparable with those of a-ANP, and were far greater than those of porcine BNP-26 reported previously. In SHR blood pressure decreased more than in WKY following injection of the highest dose (2.0 nmol/kg) of BNP-45 or a-ANP. However, WKY was more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. Moreover, a high dose of BNP-45 led to prolonged lowering of blood pressure and urinary cGMP excretion compared to a-ANP, and those features were prominent in WKY. On the other hand, BNP-45 disappeared more slowly than a-ANP, when the two peptides (2.0μg) were injected intravenously in WKY. Thus, rat BNP-45 and a-ANP had comparable hypotensive and natriuretic potency. However, the action and plasma half-life of rat BNP-45 were more prolonged.

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各種コード

  • NII論文ID(NAID)
    500000092130
  • NII著者ID(NRID)
    • 8000000092355
  • DOI(NDL)
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 000000256444
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
    • NDLデジタルコレクション
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