Studies on enhancement of productivity of monoclonal antibodies by human-human hybridomas ヒト型ハイブリドーマのモノクローナル抗体生産性増強に関する影響

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Author

    • 菅原, 卓也, 1966- スガハラ, タクヤ

Bibliographic Information

Title

Studies on enhancement of productivity of monoclonal antibodies by human-human hybridomas

Other Title

ヒト型ハイブリドーマのモノクローナル抗体生産性増強に関する影響

Author

菅原, 卓也, 1966-

Author(Another name)

スガハラ, タクヤ

University

九州大学

Types of degree

博士 (農学)

Grant ID

甲第3130号

Degree year

1993-03-26

Note and Description

博士論文

CHAPTER I GENERAL INTRODUCTION CHAPTER II IMMUNOGLOBULIN PRODUCTION STIMULATING FACTOR-II IN NAMALWA CELLS CHAPTER III PURIFICATION OF IMMUNOGLOBULIN PRODUCTION STIMULATING FACTOR -IIα(IPSF-IIα) DERIVED FROM NAMALWA CELLS CHAPTER IV CHARACTERIZATION OF IPSF-IIα CHAPTER V IDENTIFICATION OF ACTIVE SUBUNIT PEPTIDE OF IPSF-IIα CHAPTER VI IPSF ACTIVITY OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE CHAPTER VII MODES OF ACTION OF IPSF-IIα CHAPTER VIII PURIFICATION OF IMMUNOGLOBULIN PROSUCTION STIMULATING FACTOR-IIβ CHAPTER IX IDENTIFICATION OF IPSF-IIβ CHAPTER X CHARACTERIZATION OF IPSF-IIβ CHAPTER XI IPSF ACTIVITIES OF NUCLEIC ACID BINDING PROTEINS AND POLY-BASIC AMINO ACIDS CHAPTER XII VIRUS CONTAINMENT CONTINUOUS CULTURE OF ANIMAL CELLS CHAPTER XIII LARGE-SCALE, HIGH-DENSITY FREEZING OF ANIMAL CELLS AND ITS APPLICATION TO HIGH-DENSITY CULTURE CHAPTER XIV CONCLUSION

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Table of Contents

  1. CONTENTS / p1 (0003.jp2)
  2. CHAPTER I GENERAL INTRODUCTION / p1 (0009.jp2)
  3. CHAPTER II IMMUNOGLOBULIN PRODUCTION STIMULAT-ING FACTOR-II IN NAMALWA CELLS / p6 (0014.jp2)
  4. 1.Introduction / p6 (0014.jp2)
  5. 2.Materials and methods / p7 (0015.jp2)
  6. 3.Results / p9 (0017.jp2)
  7. 4.Discussion / p12 (0020.jp2)
  8. 5.Conclusion / p13 (0021.jp2)
  9. CHAPTER III PURIFICATION OF IMMUNOGLOBULIN PRODUCTION STIMULATING FACTOR -IIα(IPSF-IIα) DERIVED FROM NAMALWA CELLS / p14 (0022.jp2)
  10. 1.Introduction / p14 (0022.jp2)
  11. 2.Materials and methods / p15 (0023.jp2)
  12. 3.Results / p16 (0024.jp2)
  13. 4.Discussion / p22 (0030.jp2)
  14. 5.Conclusion / p23 (0031.jp2)
  15. CHAPTER IV CHARACTERIZATION OF IPSF-IIα / p24 (0032.jp2)
  16. 1.Introduction / p24 (0032.jp2)
  17. 2.Materials and methods / p24 (0032.jp2)
  18. 3.Results / p25 (0033.jp2)
  19. 4.Discussion / p34 (0042.jp2)
  20. 5.Conclusion / p36 (0044.jp2)
  21. CHAPTER V IDENTIFICATION OF ACTIVE SUBUNIT PEPTIDE OF IPSF-IIα / p37 (0045.jp2)
  22. 1.Introduction / p37 (0045.jp2)
  23. 2.Materials and methods / p37 (0045.jp2)
  24. 3.Results / p38 (0046.jp2)
  25. 4.Discussion / p42 (0050.jp2)
  26. 5.Conclusion / p43 (0051.jp2)
  27. CHAPTER VI IPSF ACTIVITY OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE / p44 (0052.jp2)
  28. 1.Introduction / p44 (0052.jp2)
  29. 2.Materials and method / p44 (0052.jp2)
  30. 3.Result / p46 (0054.jp2)
  31. 4.Discussion / p49 (0057.jp2)
  32. 5.Conclusion / p51 (0059.jp2)
  33. CHAPTER VII MODES OF ACTION OF IPSF-IIα / p52 (0060.jp2)
  34. 1.Introduction / p52 (0060.jp2)
  35. 2.Materials and methods / p52 (0060.jp2)
  36. 3.Results / p54 (0062.jp2)
  37. 4.Discussion / p65 (0073.jp2)
  38. 5.Conclusion / p69 (0077.jp2)
  39. CHAPTER VIII PURIFICATION OF IMMUNOGLOBULIN PROSUCTION STIMULATING FACTOR-IIβ / p70 (0078.jp2)
  40. 1.Introduction / p70 (0078.jp2)
  41. 2.Materials and methods / p70 (0078.jp2)
  42. 3.Results / p71 (0079.jp2)
  43. 4.Discussion / p77 (0085.jp2)
  44. 5.Conclusion / p78 (0086.jp2)
  45. CHAPTER IX IDENTIFICATION OF IPSF-IIβ / p79 (0087.jp2)
  46. 1.Introduction / p79 (0087.jp2)
  47. 2.Materials and methods / p79 (0087.jp2)
  48. 3.Results / p80 (0088.jp2)
  49. 4.Discussion / p84 (0092.jp2)
  50. 5.Conclusion / p85 (0093.jp2)
  51. CHAPTER X CHARACTERIZATION OF IPSF-IIβ / p86 (0094.jp2)
  52. 1.Introduction / p86 (0094.jp2)
  53. 2.Materials and methods / p86 (0094.jp2)
  54. 3.Results / p87 (0095.jp2)
  55. 4.Discussion / p93 (0101.jp2)
  56. 5.Conclusion / p95 (0103.jp2)
  57. CHAPTER XI IPSF ACTIVITIES OF NUCLEIC ACID BINDING PROTEINS AND POLY-BASIC AMINO ACIDS / p96 (0104.jp2)
  58. 1.Introduction / p96 (0104.jp2)
  59. 2.Materials and methods / p97 (0105.jp2)
  60. 3.Results / p97 (0105.jp2)
  61. 4.Discussion / p103 (0111.jp2)
  62. 5.Conclusion / p104 (0112.jp2)
  63. CHAPTER XII VIRUS CONTAINMENT CONTINUOUS CULTURE OF ANIMAL CELLS / p105 (0113.jp2)
  64. 1.Introduction / p105 (0113.jp2)
  65. 2.Materials and methods / p105 (0113.jp2)
  66. 3.Results / p108 (0116.jp2)
  67. 4.Discussion / p111 (0119.jp2)
  68. 5.Conclusion / p112 (0120.jp2)
  69. CHAPTER XIII LARGE-SCALE, HIGH-DENSITY FREEZING OF ANIMAL CELLS AND ITS APPLICATION TO HIGH-DENSITY CULTURE / p113 (0121.jp2)
  70. 1.Introduction / p113 (0121.jp2)
  71. 2.Materials and methods / p113 (0121.jp2)
  72. 3.Results / p115 (0123.jp2)
  73. 4.Discussion / p119 (0127.jp2)
  74. 5.Conclusion / p121 (0129.jp2)
  75. CHAPTER XIV CONCLUSION / p122 (0130.jp2)
  76. ACKNOWLEDGMENT / p127 (0135.jp2)
  77. REFERENCE / p128 (0136.jp2)
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Codes

  • NII Article ID (NAID)
    500000093304
  • NII Author ID (NRID)
    • 8000000952922
  • DOI(NDL)
  • Text Lang
    • eng
  • NDLBibID
    • 000000257618
  • Source
    • Institutional Repository
    • NDL ONLINE
    • NDL Digital Collections

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