Biothermodynamics of ionic drug interaction with blood components : a flow microcalorimetric study イオン性薬物と血液成分の相互作用についての生物熱力学 : フロー式ミクロカロリメトリーによる研究

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著者

    • 安藝, 初美 アキ, ハツミ

書誌事項

タイトル

Biothermodynamics of ionic drug interaction with blood components : a flow microcalorimetric study

タイトル別名

イオン性薬物と血液成分の相互作用についての生物熱力学 : フロー式ミクロカロリメトリーによる研究

著者名

安藝, 初美

著者別名

アキ, ハツミ

学位授与大学

九州大学

取得学位

博士 (薬学)

学位授与番号

乙第5339号

学位授与年月日

1993-02-12

注記・抄録

博士論文

目次

  1. Contents / p5 (0005.jp2)
  2. Glossary / p1 (0003.jp2)
  3. Introduction / p1 (0007.jp2)
  4. Part 1 Microcalorimetry / p4 (0009.jp2)
  5. Chapter 1 Calorimetric instrumentation / p4 (0009.jp2)
  6. Chapter 2 Differential flow microcalorimeter / p7 (0010.jp2)
  7. 2.1 Principle of the differential flow microcalorimeter / p7 (0010.jp2)
  8. 2.2 Instrumental design and function / p10 (0012.jp2)
  9. 2.3 Measurement modes / p14 (0014.jp2)
  10. 2.4 Sensitivity and precision of electrical calibration / p17 (0015.jp2)
  11. 2.5 Mixing efficiency and accuracy of measurements / p19 (0016.jp2)
  12. 2.6 Conclusion / p21 (0017.jp2)
  13. Part 2 Ionic drug interaction with human blood components / p22 (0018.jp2)
  14. Chapter 3 General aspects / p22 (0018.jp2)
  15. 3.1 Contribution to the thermodynamic changes with interacting system / p22 (0018.jp2)
  16. 3.2 Interpretation of the thermodynamic changes / p25 (0019.jp2)
  17. 3.3 Compensation analysis / p30 (0022.jp2)
  18. Chapter 4 Data analysis / p33 (0023.jp2)
  19. 4.1 Graphical analysis / p34 (0024.jp2)
  20. 4.2 Computation of binding and thermodynamic parameters / p36 (0025.jp2)
  21. Chapter 5 Classification of drug binding sites on human serum albumin molecule / p39 (0026.jp2)
  22. 5.1 Thermodynamic aspects of fatty acid-human serum albumin binding interactions / p40 (0027.jp2)
  23. 5.2 Classification of anionic drug binding sites to human serum albumin / p54 (0034.jp2)
  24. 5.3 Conclusion / p58 (0036.jp2)
  25. Chapter 6 Thermodynamics of the binding reaction of ionic drugs to blood components / p60 (0037.jp2)
  26. 6.1 Calorimetric titrations of drug binding to blood components / p62 (0038.jp2)
  27. 6.2 Thermodynamic aspects for drug interaction in the blood system / p76 (0045.jp2)
  28. 6.3 Conclusion / p86 (0050.jp2)
  29. Chapter 7 Drug-induced hemolysis / p89 (0051.jp2)
  30. 7.1 Percent hemolysis induced by drugs / p89 (0051.jp2)
  31. 7.2 Heat produced by human erythrocyte hemolysis / p91 (0052.jp2)
  32. 7.3 Relationship between drug binding to human intact erythrocytes and hemolysis / p97 (0055.jp2)
  33. 7.4 Drug interaction with human erythrocyte ghost membranes / p101 (0057.jp2)
  34. 7.5 Mechanism of drug-induced hemolysis / p107 (0060.jp2)
  35. 7.6 Conclusion / p111 (0062.jp2)
  36. Chapter 8.Experimental section / p113 (0063.jp2)
  37. 8.1 Materials / p113 (0063.jp2)
  38. 8.2 Experimental methods / p115 (0064.jp2)
  39. Concluding remarks / p118 (0066.jp2)
  40. Acknowledgements / p121 (0067.jp2)
  41. Abbreviations / p122 (0068.jp2)
  42. References / p124 (0069.jp2)
  43. List of published papers / p135 (0074.jp2)
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各種コード

  • NII論文ID(NAID)
    500000093363
  • NII著者ID(NRID)
    • 8000000093589
  • DOI(NDL)
  • NDL書誌ID
    • 000000257677
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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