Fundamental studies on application of saccharides and polysaccharides for drug delivery system 糖類および多糖類のドラッグ・デリバリー・システムへの応用に関する基礎的研究

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著者

    • 大矢, 裕一 オオヤ, ユウイチ

書誌事項

タイトル

Fundamental studies on application of saccharides and polysaccharides for drug delivery system

タイトル別名

糖類および多糖類のドラッグ・デリバリー・システムへの応用に関する基礎的研究

著者名

大矢, 裕一

著者別名

オオヤ, ユウイチ

学位授与大学

京都大学

取得学位

博士 (工学)

学位授与番号

乙第8153号

学位授与年月日

1993-03-23

注記・抄録

博士論文

目次

  1. 論文目録 / (0001.jp2)
  2. TABLE OF CONTENTS / p1 (0006.jp2)
  3. List of Abbrebiations / p3 (0007.jp2)
  4. General Introduction / p1 (0008.jp2)
  5. Part I Design of Macromolecular Prodrugs of 5-Fluorouracil Using Polysaccharides as Carriers / (0013.jp2)
  6. Chapter 1 Synthesis and Antitumor Activity of α-1,4-Polygalactosamine and N-Acetyl-α-1,4-polygalactosamine Immobilizing 5-Fluorouracils through Hexamethylene Spacer Groups and Two Urea Bonds / p13 (0014.jp2)
  7. Chapter 2 Synthesis and Antitumor Activity of Carboxymethylchitin Immobilizing 5-Fluorouracils through Pentamethylene and Monomethylene Spacer Groups,via Amide and Ester Bonds / p27 (0021.jp2)
  8. Chapter 3 Synthesis and Antitumor Activity of Carboxymethyl-N-acetyl-α-1,4-polygalactosamine Immobilizing 5-Fluorouracils / p33 (0024.jp2)
  9. Part II Design of Macromolecular Prodrugs of 5-Fluorouracil and Adriamycin Using Poly(α-malic acid)as Carrier and Saccharide Residues as Targeting Moieties / (0031.jp2)
  10. Chapter 4 Synthesis and Antitumor Activity of Poly(α-malic acid)/5-Fluorouracil Conjugates Having Saccharide Residues as Targeting Moieties / p49 (0032.jp2)
  11. Chapter 5 Synthesis and Antitumor Activity of Poly(α-malic acid)Immobilizing Adriamycins through Amide or Ester Bond / p65 (0040.jp2)
  12. Chapter 6 Synthesis and Cell Specific Cytotoxic Activity of Poly(α-malic acid) Immobilizing Adriamycins and Saccharide Residues / p75 (0045.jp2)
  13. Part III Controlled Delivery of 5-Fluorouracil by Chitosan Microspheres and Albumin Microspheres / (0051.jp2)
  14. Chapter 7 Preparation of Albumin Microspheres Immobilizing Galactose Residues through Poly(ethylenglycol)Spacers and Release Behavior of 5-Fluorouracil from Them / p89 (0052.jp2)
  15. Chapter 8 Release Behavior of 5-Fluorouracil from Chitosan-gel Microspheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell-specific Recognition / p107 (0061.jp2)
  16. Chapter 9 Thermo-sensitive Release Behavior of 5-Fluorouracil from Chitosan-gel Microspheres Coated with Lipid Multilayers / p119 (0067.jp2)
  17. Concluding Remarks / p133 (0074.jp2)
  18. List of Publications / p139 (0077.jp2)
  19. Acknowledgements / p143 (0079.jp2)
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各種コード

  • NII論文ID(NAID)
    500000094259
  • NII著者ID(NRID)
    • 8000000094485
  • DOI(NDL)
  • NDL書誌ID
    • 000000258573
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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