Fundamental studies on application of saccharides and polysaccharides for drug delivery system 糖類および多糖類のドラッグ・デリバリー・システムへの応用に関する基礎的研究
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著者
書誌事項
- タイトル
-
Fundamental studies on application of saccharides and polysaccharides for drug delivery system
- タイトル別名
-
糖類および多糖類のドラッグ・デリバリー・システムへの応用に関する基礎的研究
- 著者名
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大矢, 裕一
- 著者別名
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オオヤ, ユウイチ
- 学位授与大学
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京都大学
- 取得学位
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博士 (工学)
- 学位授与番号
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乙第8153号
- 学位授与年月日
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1993-03-23
注記・抄録
博士論文
目次
- 論文目録 (1コマ目)
- TABLE OF CONTENTS/p1 (6コマ目)
- List of Abbrebiations/p3 (7コマ目)
- General Introduction/p1 (8コマ目)
- Part I Design of Macromolecular Prodrugs of 5-Fluorouracil Using Polysaccharides as Carriers (13コマ目)
- Chapter 1 Synthesis and Antitumor Activity of α-1,4-Polygalactosamine and N-Acetyl-α-1,4-polygalactosamine Immobilizing 5-Fluorouracils through Hexamethylene Spacer Groups and Two Urea Bonds/p13 (14コマ目)
- Chapter 2 Synthesis and Antitumor Activity of Carboxymethylchitin Immobilizing 5-Fluorouracils through Pentamethylene and Monomethylene Spacer Groups,via Amide and Ester Bonds/p27 (21コマ目)
- Chapter 3 Synthesis and Antitumor Activity of Carboxymethyl-N-acetyl-α-1,4-polygalactosamine Immobilizing 5-Fluorouracils/p33 (24コマ目)
- Part II Design of Macromolecular Prodrugs of 5-Fluorouracil and Adriamycin Using Poly(α-malic acid)as Carrier and Saccharide Residues as Targeting Moieties (31コマ目)
- Chapter 4 Synthesis and Antitumor Activity of Poly(α-malic acid)/5-Fluorouracil Conjugates Having Saccharide Residues as Targeting Moieties/p49 (32コマ目)
- Chapter 5 Synthesis and Antitumor Activity of Poly(α-malic acid)Immobilizing Adriamycins through Amide or Ester Bond/p65 (40コマ目)
- Chapter 6 Synthesis and Cell Specific Cytotoxic Activity of Poly(α-malic acid) Immobilizing Adriamycins and Saccharide Residues/p75 (45コマ目)
- Part III Controlled Delivery of 5-Fluorouracil by Chitosan Microspheres and Albumin Microspheres (51コマ目)
- Chapter 7 Preparation of Albumin Microspheres Immobilizing Galactose Residues through Poly(ethylenglycol)Spacers and Release Behavior of 5-Fluorouracil from Them/p89 (52コマ目)
- Chapter 8 Release Behavior of 5-Fluorouracil from Chitosan-gel Microspheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell-specific Recognition/p107 (61コマ目)
- Chapter 9 Thermo-sensitive Release Behavior of 5-Fluorouracil from Chitosan-gel Microspheres Coated with Lipid Multilayers/p119 (67コマ目)
- Concluding Remarks/p133 (74コマ目)
- List of Publications/p139 (77コマ目)
- Acknowledgements/p143 (79コマ目)