Genetical, pharmacological and molecular studies on ketamine response of the nematode Caenorhabditis elegans 線虫C.エレガンスのケタミン応答の遺伝学的,薬理学的及び分子生物学的研究

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Author

    • 安藤, 秀樹 アンドウ, ヒデキ

Bibliographic Information

Title

Genetical, pharmacological and molecular studies on ketamine response of the nematode Caenorhabditis elegans

Other Title

線虫C.エレガンスのケタミン応答の遺伝学的,薬理学的及び分子生物学的研究

Author

安藤, 秀樹

Author(Another name)

アンドウ, ヒデキ

University

岡山大学

Types of degree

博士 (理学)

Grant ID

甲第1143号

Degree year

1993-03-28

Note and Description

博士論文

Table of Contents

  1. CONTENTS / p2 (0004.jp2)
  2. Abbreviations / p5 (0007.jp2)
  3. List of tables / p6 (0008.jp2)
  4. List of figures / p7 (0009.jp2)
  5. 1.Summary / p9 (0011.jp2)
  6. 2.Introduction / p13 (0015.jp2)
  7. 2.1 Caenorhabditis elegans as a model for higher organisms / p13 (0015.jp2)
  8. 2.2 The problems in muscle contraction mechanisms / p15 (0017.jp2)
  9. 2.3 Muscle contraction mechanisms in C.elegans / p20 (0022.jp2)
  10. 3.Materials and Methods / p23 (0025.jp2)
  11. 3.1 Mutant isolation / p23 (0025.jp2)
  12. 3.2 Complementation tests / p23 (0025.jp2)
  13. 3.3 Mapping / p24 (0026.jp2)
  14. 3.4 Measurement of motility in temperature shift / p26 (0028.jp2)
  15. 3.5 Cut worm assay / p26 (0028.jp2)
  16. 3.6 Materials for genetical and pharmacological assays / p27 (0029.jp2)
  17. 3.7 Cosmid clones and C.elegans physical maps / p29 (0031.jp2)
  18. 3.8 Marker rescue experiment by DNA-mediated transformation / p29 (0031.jp2)
  19. 3.9 Northern hybridization / p30 (0032.jp2)
  20. 3.10 Genomic DNA and cDNA manipulations and sequencing / p30 (0032.jp2)
  21. 4.Results / p32 (0034.jp2)
  22. 4.1 Pharmacological effects of ketamine on C.elegans / p32 (0034.jp2)
  23. 4.2 Phenotypes of KRA mutants / p33 (0035.jp2)
  24. 4.3 Identification of kra-1(unc-68)gene / p42 (0044.jp2)
  25. 4.4 Comparison of the drug sensitivities of kh30 and other mutant animals / p45 (0047.jp2)
  26. 4.5 Cut worm assays on wild-type and kh30 worms in coexistence of ketamine and cholinergic blockers / p51 (0053.jp2)
  27. 4.6 Sensitivities of wild-type and kh30 animals to NMDA receptor agents / p54 (0056.jp2)
  28. 4.7 Mapping of transcripts within unc-68 region by RNA blot analyses / p55 (0057.jp2)
  29. 4.8 A 0.5 kb transcript rescued unc-68 muscle contraction / p55 (0057.jp2)
  30. 4.9 Stage specific expression of 0.5 kb transcript in wild-type nematode / p65 (0067.jp2)
  31. 4.10 Sequence analysis of cDNA and genomic DNA of unc-68-rescuing gene / p65 (0067.jp2)
  32. 5.Discussion / p79 (0081.jp2)
  33. 5.1 Mutations in ketamine response abnormal / p79 (0081.jp2)
  34. 5.2 Ketamine action on wild-type and mutant worms / p79 (0081.jp2)
  35. 5.3 Similar effects of unc-68 mutation and ketamine on nematode muscle / p81 (0083.jp2)
  36. 5.4 Character of kh30 mutation / p81 (0083.jp2)
  37. 5.5 Importance of minor expression of unc-68-rescuing gene / p83 (0085.jp2)
  38. 5.6 Structure of gene and its product of unc-68-rescuing gene / p83 (0085.jp2)
  39. 5.7 A possible model for deduced 13.5K protein / p84 (0086.jp2)
  40. 6.Conclusion / p88 (0090.jp2)
  41. 7.References / p89 (0091.jp2)
  42. Acknowledgments / p96 (0098.jp2)
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Codes

  • NII Article ID (NAID)
    500000094363
  • NII Author ID (NRID)
    • 8000000094589
  • DOI(NDL)
  • Text Lang
    • jpn
  • NDLBibID
    • 000000258677
  • Source
    • Institutional Repository
    • NDL ONLINE
    • NDL Digital Collections

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