Genetical, pharmacological and molecular studies on ketamine response of the nematode Caenorhabditis elegans 線虫C.エレガンスのケタミン応答の遺伝学的,薬理学的及び分子生物学的研究

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著者

    • 安藤, 秀樹 アンドウ, ヒデキ

書誌事項

タイトル

Genetical, pharmacological and molecular studies on ketamine response of the nematode Caenorhabditis elegans

タイトル別名

線虫C.エレガンスのケタミン応答の遺伝学的,薬理学的及び分子生物学的研究

著者名

安藤, 秀樹

著者別名

アンドウ, ヒデキ

学位授与大学

岡山大学

取得学位

博士 (理学)

学位授与番号

甲第1143号

学位授与年月日

1993-03-28

注記・抄録

博士論文

目次

  1. CONTENTS / p2 (0004.jp2)
  2. Abbreviations / p5 (0007.jp2)
  3. List of tables / p6 (0008.jp2)
  4. List of figures / p7 (0009.jp2)
  5. 1.Summary / p9 (0011.jp2)
  6. 2.Introduction / p13 (0015.jp2)
  7. 2.1 Caenorhabditis elegans as a model for higher organisms / p13 (0015.jp2)
  8. 2.2 The problems in muscle contraction mechanisms / p15 (0017.jp2)
  9. 2.3 Muscle contraction mechanisms in C.elegans / p20 (0022.jp2)
  10. 3.Materials and Methods / p23 (0025.jp2)
  11. 3.1 Mutant isolation / p23 (0025.jp2)
  12. 3.2 Complementation tests / p23 (0025.jp2)
  13. 3.3 Mapping / p24 (0026.jp2)
  14. 3.4 Measurement of motility in temperature shift / p26 (0028.jp2)
  15. 3.5 Cut worm assay / p26 (0028.jp2)
  16. 3.6 Materials for genetical and pharmacological assays / p27 (0029.jp2)
  17. 3.7 Cosmid clones and C.elegans physical maps / p29 (0031.jp2)
  18. 3.8 Marker rescue experiment by DNA-mediated transformation / p29 (0031.jp2)
  19. 3.9 Northern hybridization / p30 (0032.jp2)
  20. 3.10 Genomic DNA and cDNA manipulations and sequencing / p30 (0032.jp2)
  21. 4.Results / p32 (0034.jp2)
  22. 4.1 Pharmacological effects of ketamine on C.elegans / p32 (0034.jp2)
  23. 4.2 Phenotypes of KRA mutants / p33 (0035.jp2)
  24. 4.3 Identification of kra-1(unc-68)gene / p42 (0044.jp2)
  25. 4.4 Comparison of the drug sensitivities of kh30 and other mutant animals / p45 (0047.jp2)
  26. 4.5 Cut worm assays on wild-type and kh30 worms in coexistence of ketamine and cholinergic blockers / p51 (0053.jp2)
  27. 4.6 Sensitivities of wild-type and kh30 animals to NMDA receptor agents / p54 (0056.jp2)
  28. 4.7 Mapping of transcripts within unc-68 region by RNA blot analyses / p55 (0057.jp2)
  29. 4.8 A 0.5 kb transcript rescued unc-68 muscle contraction / p55 (0057.jp2)
  30. 4.9 Stage specific expression of 0.5 kb transcript in wild-type nematode / p65 (0067.jp2)
  31. 4.10 Sequence analysis of cDNA and genomic DNA of unc-68-rescuing gene / p65 (0067.jp2)
  32. 5.Discussion / p79 (0081.jp2)
  33. 5.1 Mutations in ketamine response abnormal / p79 (0081.jp2)
  34. 5.2 Ketamine action on wild-type and mutant worms / p79 (0081.jp2)
  35. 5.3 Similar effects of unc-68 mutation and ketamine on nematode muscle / p81 (0083.jp2)
  36. 5.4 Character of kh30 mutation / p81 (0083.jp2)
  37. 5.5 Importance of minor expression of unc-68-rescuing gene / p83 (0085.jp2)
  38. 5.6 Structure of gene and its product of unc-68-rescuing gene / p83 (0085.jp2)
  39. 5.7 A possible model for deduced 13.5K protein / p84 (0086.jp2)
  40. 6.Conclusion / p88 (0090.jp2)
  41. 7.References / p89 (0091.jp2)
  42. Acknowledgments / p96 (0098.jp2)
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各種コード

  • NII論文ID(NAID)
    500000094363
  • NII著者ID(NRID)
    • 8000000094589
  • DOI(NDL)
  • 本文言語コード
    • jpn
  • NDL書誌ID
    • 000000258677
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
    • NDLデジタルコレクション
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