Synthesis and evaluation of ester prodrugs to improve the oral delivery of propranolol 吸収性の改善を目的としたプロプラノロールプロドラッグの合成と評価
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Bibliographic Information
- Title
-
Synthesis and evaluation of ester prodrugs to improve the oral delivery of propranolol
- Other Title
-
吸収性の改善を目的としたプロプラノロールプロドラッグの合成と評価
- Author
-
Shameem, Mohammed
- Author(Another name)
-
シャーミム, モハメド
- University
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熊本大学
- Types of degree
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博士 (薬学)
- Grant ID
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甲第22号
- Degree year
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1993-03-25
Note and Description
博士論文
Table of Contents
- Contents / (0004.jp2)
- General Introduction / p1 (0005.jp2)
- Chapter1.Design of Prodrugs:Synthesis and Kinetic Studies / p9 (0009.jp2)
- 1.1.Introduction / p10 (0010.jp2)
- 1.2.Results and Discussion / p11 (0010.jp2)
- Chapter2.Oral Bioavailability Evaluation of Prodrugs / p23 (0016.jp2)
- 2.1.Introduction / p24 (0017.jp2)
- 2.2.Results and Discussion / p25 (0017.jp2)
- Chapter3.Stereoselective Hydrolysis of Prodrugs / p31 (0020.jp2)
- 3.1.Introduction / p32 (0021.jp2)
- 3.2.Results and Discussion / p32 (0021.jp2)
- Chapter4.Stereoselective Oral Bioavailability Evaluation of O-Isovaleryl Propranolol / p41 (0025.jp2)
- 4.1.Introduction / p42 (0026.jp2)
- 4.2.Results and Discussion / p42 (0026.jp2)
- Summary / p49 (0029.jp2)
- Concluding Remarks / p52 (0031.jp2)
- Materials and Methods / p53 (0031.jp2)
- 1.Apparatus / p53 (0031.jp2)
- 2.Materials / p53 (0031.jp2)
- 3.Methods / p54 (0032.jp2)
- Acknowledgements / p62 (0036.jp2)
- References and Notes / p64 (0037.jp2)