Studies on the production of human monoclonal antibodies by serum-free culture of hybridomas ハイブリドーマの無血清培養によるヒト型モノクローナル抗体の生産に関する研究
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Bibliographic Information
- Title
-
Studies on the production of human monoclonal antibodies by serum-free culture of hybridomas
- Other Title
-
ハイブリドーマの無血清培養によるヒト型モノクローナル抗体の生産に関する研究
- Author
-
新谷, 靖
- Author(Another name)
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シンタニ, ヤスシ
- University
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京都大学
- Types of degree
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博士 (農学)
- Grant ID
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乙第8252号
- Degree year
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1993-05-24
Note and Description
博士論文
Table of Contents
- 論文目録 / (0001.jp2)
- CONTENTS / p1 (0004.jp2)
- INTRODUCTION / p2 (0005.jp2)
- CHAPTER I. Improvement of cell lines for effective production of human MoAbs / p5 (0006.jp2)
- PART 1. Selection of high productivity subclones of a (mouse.human-human) heterohybridoma / p5 (0006.jp2)
- PART 2. Improvement of high productivity clones of human-human hybridomas / p13 (0010.jp2)
- CHAPTER II. Establishment of serum-free media containing polyethylene glycol / p18 (0013.jp2)
- PART 1. PEGs for promoting the growth of mammalian cells / p18 (0013.jp2)
- PART 2. SSGF-I,another potent growth promoting substance for mammalian cells / p27 (0017.jp2)
- PART 3. Role of SSGF-I on growth of a high productivity subclone of a(m.h-h) heterohybridoma / p38 (0023.jp2)
- CHAPTER III. Development of effective culture systems / p50 (0029.jp2)
- PART 1. Effective production of human MoAbs by batch culture of the hybridomas in serum-free media / p50 (0029.jp2)
- PART 2. MoAbs production kinetics in the human-human hybridomas / p56 (0032.jp2)
- PART 3. Effective long-term perfusion culture for the human-human hybridomas / p68 (0038.jp2)
- CHAPTER IV. Large-scale purification of human MoAbs / p79 (0043.jp2)
- CONCLUSION / p85 (0046.jp2)
- ACKNOWLEDGEMENTS / p86 (0047.jp2)