Pattern of response to interstitial hyperthermia and brachytherapy for malignant intracranial tumor : a CT analysis 頭蓋内悪性腫瘍に対する組織内温熱・放射線併用療法の臨床効果 : CT画像による分析

博士論文

Interstitial microwave hyperthermia in combination with iridium-192 brachytherapy has been administered to 23 cases of malignant brain tumours in a phase one clinical trial to assess the feasibility and safety of this treatment. In order to quantify the acute and long-term response of tumour and surrounding brain to this treatment, a morphometric computed tomography scan analysis was performed in 18 evaluable patients. Volumes defined by the outer margin of the contrast-enhancing rim, by the hypodense necrotic region within the enhancing rim and by the surrounding hypodensity region were calculated from computer measurements. Hyperthermia equipment performance (HEP) was calculated for the evaluation of heating. After the treatments, the volume of the inner hypodensity region decreased in seven patients and the volume increased in 11 patients. In five patients, the outer margin of the contrast-enhancing lesion showed an initial increase in volume followed by a decrease and in these patients higher HEP and longer survival were observed significantly. The volume of the surrounding hypodensity region varied following treatments, but in most instances, the region subsequently increased in the interval immediately prior to death. Contribution of heat effect to these changes are discussed and the significance of aggressive heating, which provides transient opening of blood brain barrier, is shown.

学位の種類: 博士（医学）. 報告番号: 甲第891号. 学位記番号: 新大院博（医）甲第666号. 学位授与年月日: 平成5年3月22日

International Journal of Hyperthermia. 1993, 9(4), 491-502.

新大院博（医）甲第666号