Opioid-regulated pharmacological interaction and intracellular signaling mechanism

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著者

    • 成田, 年 ナリタ, ミノル

書誌事項

タイトル

Opioid-regulated pharmacological interaction and intracellular signaling mechanism

著者名

成田, 年

著者別名

ナリタ, ミノル

学位授与大学

星薬科大学

取得学位

博士 (薬学)

学位授与番号

甲第53号

学位授与年月日

1993-03-15

注記・抄録

博士論文

1992年度

目次

  1. TABLE OF CONTENTS / p1 (0003.jp2)
  2. GENERAL INTRODUCTION / p1 (0007.jp2)
  3. CHAPTER1 / p11 (0012.jp2)
  4. EFFECTS OF κ AGONISTS ON THE MORPHINE-INDUCED ANTINOCICEPTION, LOCOMOTION, STRAUB TAIL AND INCREASE IN DOPAMINE TURNOVER IN MICE / p11 (0012.jp2)
  5. EXPERIMENT1-1: Effects of κ agonist on the morphine-induced supraspinal antinociception / p15 (0014.jp2)
  6. EXPERIMENT1-2: Blockade of the morphine-induced hyperlocomotion by κ agonists in mice / p24 (0019.jp2)
  7. EXPERIMENT1-3: Antagonism of the morphine-induced Straub tail reaction by κ opioid receptor activation in mice / p35 (0024.jp2)
  8. EXPERIMENT1-4: Blockade of the morphine-induced increase in turnover of dopamine in the mesolimbic dopaminergic system by κ agonist in mice / p39 (0026.jp2)
  9. EXPERIMENT1-5: Lack of blockade of the morphine-induced increase in turnover of serotonin in the limbic forebrain by κ agonist in mice / p49 (0031.jp2)
  10. EXPERIMENT1-6: Interaction among the opioid receptor types in the double-enkephalins-induced antinociception and locomotor enhancing action in mice / p53 (0033.jp2)
  11. Discussion / p59 (0036.jp2)
  12. CHAPTER2 / p81 (0047.jp2)
  13. ROLE OF κ RECEPTORS IN THE DEVELOPMENT OF ANTINOCICEPTIVE TOLERANCE TO AND PHYSICAL DEPENDENCE ON MORPHINE / p81 (0047.jp2)
  14. EXPERIMENT2-1: Effects of κ agonist and dopamine blockers on the development of antinociceptive tolerance to morphine in mice / p84 (0049.jp2)
  15. EXPERIMENT2-2: Effects of κ antagonist on the development of tolerance to morphine antinociception in mice / p88 (0051.jp2)
  16. EXPERIMENT2-3: Effects of κ antagonist on the development of physical dependence on morphine in mice and rats / p94 (0054.jp2)
  17. Discussion / p102 (0058.jp2)
  18. CHAPTER3 / p108 (0061.jp2)
  19. ROLE OF CENTRAL ATP-SENSITIVE K⁺ CHANNELS IN THE MORPHINE-INDUCED PHARMACOLOGICAL ACTIONS / p108 (0061.jp2)
  20. EXPERIMENT3-1: Involvement of central ATP-sensitive K⁺ channel in the morphine-induced antinociception in mice / p110 (0062.jp2)
  21. EXPERIMENT3-2: Direct opeing of central ATP-sensitive K⁺ channels produces the antinociception in mice / p115 (0064.jp2)
  22. EXPERIMENT3-3: Lack of displacement of ³H-glibenclamide bindings by morphine in the mouse brain / p119 (0066.jp2)
  23. EXPERIMENT3-4: Involvement of central ATP-sensitive K⁺ channels in the spinal noradrenaline turnover-enhancing effect of intracere-broventricularly injected morphine in mice / p123 (0068.jp2)
  24. EXPERIMENT3-5: Direct opening of central ATP-sensitive K⁺ channels produces the spinal noradrenaline turnover-enhancing effect in mice / p128 (0071.jp2)
  25. EXPERIMENT3-6: Role of central ATP-sensitive K⁺ channels in the hyperthermic effect of morphine in mice / p131 (0072.jp2)
  26. EXPERIMENT3-7: Blockade of central ATP-sensitive K⁺ channels abolishes the potentiating effect of morphine on the bicucullineinduced convulsion in mice / p134 (0074.jp2)
  27. EXPERIMENT3-8: Lack of changes in central ATP-sensitive K⁺ channels in the morphine-tolerant mice / p139 (0076.jp2)
  28. Discussion / p147 (0080.jp2)
  29. SUMMARY / p161 (0087.jp2)
  30. ACKNOWLEDGEMENTS / p167 (0090.jp2)
  31. REFERENCES / p168 (0091.jp2)
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各種コード

  • NII論文ID(NAID)
    500000096751
  • NII著者ID(NRID)
    • 8000000096978
  • DOI(NDL)
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 000000261065
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
    • NDLデジタルコレクション
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