Microdialysis as a technique to determine the in vivo unbound drug concentration in tissue interstitial fluid and its application to tissue distribution study of drugs 微小透析法による組織細胞間質液中非結合形薬物濃度測定法の確立と薬物組織分布動態研究への応用
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著者
書誌事項
- タイトル
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Microdialysis as a technique to determine the in vivo unbound drug concentration in tissue interstitial fluid and its application to tissue distribution study of drugs
- タイトル別名
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微小透析法による組織細胞間質液中非結合形薬物濃度測定法の確立と薬物組織分布動態研究への応用
- 著者名
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出口, 芳春
- 著者別名
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デグチ, ヨシハル
- 学位授与大学
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金沢大学
- 取得学位
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博士 (薬学)
- 学位授与番号
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乙第1234号
- 学位授与年月日
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1992-09-30
注記・抄録
博士論文
目次
- List of Contents / p2 (0006.jp2)
- Acknowledgments / p1 (0005.jp2)
- List of Contents / p2 (0006.jp2)
- List of Tables / p5 (0009.jp2)
- List of Figures / p7 (0011.jp2)
- Chapter1 General Introduction / p1 (0013.jp2)
- A.Microdialysis Technique and Its Application / p2 (0014.jp2)
- B.The Purpose of This Thesis / p6 (0018.jp2)
- C.References / p8 (0020.jp2)
- Chapter2 Muscle Microdialysis as A Model Study to Relate the Drug Concentration in Tissue Interstitial Fluid and Dialysate:Proposal of the Extrapolation Methop for Determining the In Vivo Unbound Concentration in Tissue Interstitial Fluid / p12 (0024.jp2)
- A.Summary / p13 (0025.jp2)
- B.Introduction / p14 (0026.jp2)
- C.Materials and Method / p15 (0027.jp2)
- D.Results / p22 (0034.jp2)
- E.Discussion / p25 (0037.jp2)
- F.Appendix / p31 (0043.jp2)
- G.Reference / p33 (0045.jp2)
- H.Table / p36 (0048.jp2)
- I.Legend for Figures / p37 (0049.jp2)
- J.Figures / p39 (0051.jp2)
- Chapter3 Demonstration of Usefulness of the Proposed Method to Estimate the Unbound Concentration in Tissue Interstitial Fluid by Microdialysis and an Application to Tissue Distribution Study of Drug / p44 (0056.jp2)
- A.Summary / p45 (0057.jp2)
- B.Introduction / p46 (0058.jp2)
- C.Theoretical / p48 (0060.jp2)
- D.Materials and Methods / p51 (0063.jp2)
- E.Results / p57 (0069.jp2)
- F.Discussion / p61 (0073.jp2)
- G.Reference / p66 (0078.jp2)
- H.Tables / p69 (0081.jp2)
- I.Legend for Figures / p73 (0085.jp2)
- J.Figures / p74 (0086.jp2)
- Chapter4 Determination of In Vivo Steady State Unbound Drug Concentration in the Brain Interstitial Fluid by Microdialysis / p78 (0090.jp2)
- A.Summary / p79 (0091.jp2)
- B.Introduction / p80 (0092.jp2)
- C.Materials and Methods / p82 (0094.jp2)
- D.Results / p90 (0102.jp2)
- E.Discussion / p93 (0105.jp2)
- F.Reference / p98 (0110.jp2)
- G.Tables / p103 (0115.jp2)
- H.Legend for Figure / p107 (0119.jp2)
- I.Figure / p108 (0120.jp2)
- Chapter5 In Vivo Transport of a Dynorphin-like Analgesic Peptide,E-2078,through the Blood-Brain Barrier:An Application of Brain Microdialysis / p109 (0121.jp2)
- A.Summary / p110 (0122.jp2)
- B.Introduction / p112 (0124.jp2)
- C.Materials and Methods / p114 (0126.jp2)
- D.Results / p121 (0133.jp2)
- E.Discussion / p124 (0136.jp2)
- F.Reference / p129 (0141.jp2)
- G.Tables / p132 (0144.jp2)
- H.Legend for Figures / p134 (0146.jp2)
- I.Figures / p136 (0148.jp2)
- Chapter6 Conclusion / p140 (0152.jp2)