Drug delivery system and its mechanism by 6-O-carboxymethyl-chitin 6-O-カルボキシメチルキチンによる薬物輸送とその機構
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著者
書誌事項
- タイトル
-
Drug delivery system and its mechanism by 6-O-carboxymethyl-chitin
- タイトル別名
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6-O-カルボキシメチルキチンによる薬物輸送とその機構
- 著者名
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三浦, 嘉晃
- 著者別名
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ミウラ, ヨシアキ
- 学位授与大学
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北海道大学
- 取得学位
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博士 (理学)
- 学位授与番号
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乙第4223号
- 学位授与年月日
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1993-03-25
注記・抄録
博士論文
目次
- Contents / (0003.jp2)
- ABSTRACT / p1 (0004.jp2)
- INTRODUCTION / p3 (0005.jp2)
- CHAPTER1.Preparation of CM-chitin-drug conjugate / p17 (0012.jp2)
- Introduction / p17 (0012.jp2)
- 1.Molecular design of prodrug with amide bond as second cleavage site / p18 (0013.jp2)
- 2.Molecular design of prodrug with ester bond as second cleavage site / p25 (0016.jp2)
- Conclusion / p31 (0019.jp2)
- CHAPTER2.Biological properties of CM-chitin-drug Conjugates / p33 (0020.jp2)
- Introduction / p33 (0020.jp2)
- 1.Lysozyme susceptibility of CM-chitin and CM-chitin-drug conjugate / p34 (0021.jp2)
- 2.Immunogenicity of CM-chitin-drug conjugate / p49 (0028.jp2)
- Conclusion / p56 (0032.jp2)
- CHAPTER3.Drug release from the CM-chitin-drug conjugate / p57 (0032.jp2)
- Introduction / p57 (0032.jp2)
- 1.Release of active drug from amide bonded prodrug / p58 (0033.jp2)
- 2.Release of active drug from ester bonded prodrug / p71 (0039.jp2)
- Conclusion / p78 (0043.jp2)
- CHAPTER4.Drug stabilization by CM-chitin-Ca²⁺ complex / p79 (0043.jp2)
- Introduction / p79 (0043.jp2)
- 1.Adsorption and sustained release of drug from the complex / p82 (0045.jp2)
- 2.Local environment of calcium in the CM-chitin-Ca²⁺ complex / p97 (0052.jp2)
- Conclusion / p107 (0057.jp2)
- CONCLUDING REMARKS / p109 (0058.jp2)
- ACKNOWLEDGEMENT / p111 (0059.jp2)
- REFERENCES / p113 (0060.jp2)
- Carboxymethyl-Chitin as a Drug Carrier of Sustained Release / (0065.jp2)
- PREPARATION OF BACTERIAL POLYSACCHARIDE OF HIBRIDIZED ENZYME SUSCEPTIBILITY / p456 (0072.jp2)
- BIOSYNTESIS OF HIGHLY ORIENTATED BACTERIAL CELLULOSE UNDER STIRRED CULTURE OF ACETOBACTER XYLINUM / (0077.jp2)
- Antimetastatic activity of neocarzinostatin incorporated into controlled release gels of CM-chitin / p29 (0079.jp2)
- Susceptibilities of bacterial cellulose containing N-acetylglucosamine residues for cellulolytic and chitinolytic enzymes / (0084.jp2)
- Modification of Chitin by Ceric Salt-initiated Graft Polymerization-Preparation of Poly(methyl methacrylate)-grafted Chitin Derivatives with Swelling Property in Organic Solvent- / p1 (0093.jp2)
- CONTROLLED RELEASE AND HYDROLYSIS OF PRODRUG USING CARBOXYMETHYL-CHITIN AS A DRUG CARRIER / (0103.jp2)
- PHOTO-INDUCED ELECTROCONDUCTIVITY BY HEMATOPROPHYRIN IX DOPED CHITOSAN FILMS / p586 (0107.jp2)
- BIOSYNTHESIS OF CELLULOSE SUSCEPTIBLE FOR CHITINOLYTIC ENZYME BY ACETOBACTER SP / p323 (0115.jp2)
- Incorporation of GlcNAc residue into bacterial cellulose by A.xylinum-Characterization of a novel BC- / (0126.jp2)
- DIRECT MEASUREMENT OF LYSOZYMIC ACTIVITY BY NOVEL BACTERIAL CELLULOSE CONTAINING N-ACETYLGLUCOSAMINE RESIDUES / (0129.jp2)
- PHOTO-SWITCHING PROPERTY OF PORPHYRIN-DOPED CHITOSAN FILMS / (0132.jp2)
- Drug Delivery System Using Biodegradable Carrier / p13 (0136.jp2)
