Antitumor activities and immunological studies by fucoidan (GIV-A) prepared from Sargassum thunbergii 褐藻ウミトラノオ由来フコイダンの抗腫瘍作用と免疫学的研究

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著者

    • 伊藤, 浩子 イトウ, ヒロコ

書誌事項

タイトル

Antitumor activities and immunological studies by fucoidan (GIV-A) prepared from Sargassum thunbergii

タイトル別名

褐藻ウミトラノオ由来フコイダンの抗腫瘍作用と免疫学的研究

著者名

伊藤, 浩子

著者別名

イトウ, ヒロコ

学位授与大学

三重大学

取得学位

博士 (学術)

学位授与番号

甲第533号

学位授与年月日

1996-03-25

注記・抄録

博士論文

目次

  1. CONTENTS / (0003.jp2)
  2. 1.Introduction / p1 (0005.jp2)
  3. 2.Materials / p4 (0008.jp2)
  4. 1)Algal specimens / p4 (0008.jp2)
  5. 2)Extraction, fractionation and purification of polysaccharides from seaweed / p4 (0008.jp2)
  6. 3)Chemical and physicochemical properties. / p6 (0010.jp2)
  7. 4)Chemicals / p7 (0011.jp2)
  8. 5)Animals / p7 (0011.jp2)
  9. 6)Tumors / p7 (0011.jp2)
  10. 3.Methods / p9 (0013.jp2)
  11. 1)Evaluation of antitumor activity on EAC / p9 (0013.jp2)
  12. 2)Evaluation of antitumor activity on 3LL / p9 (0013.jp2)
  13. 3)Cytocidal antitumor test / p10 (0014.jp2)
  14. 4)Assay of carbon clearance activity / p10 (0014.jp2)
  15. 5)Assay of crossed immunoelectrophoresis / p11 (0015.jp2)
  16. 6)Phagocytosis and ingestion of polystyrene latex beads / p12 (0016.jp2)
  17. 7)Preparation of effecter cells / p13 (0017.jp2)
  18. 8)The third component of complement(C3)cleavage product binding assay / p14 (0018.jp2)
  19. 9)Luminol-dependent chemiluminescence assay / p14 (0018.jp2)
  20. 10)Assay of residual CH50 / p15 (0019.jp2)
  21. 11)Picryl chloride-induced delayed type hypersensitivity / p15 (0019.jp2)
  22. 12)Assay of liver, spleen and thymus weights, number of spleen cells and quantitative hemolysis of sheep red blood cells(SRBC)[QHS] / p16 (0020.jp2)
  23. 13)Analysis of splenic lymphocyte subsets / p16 (0020.jp2)
  24. 14)Assay of hepatic drug-metabolizing enzyme / p18 (0022.jp2)
  25. 15)Assay of 5-FU / p19 (0023.jp2)
  26. 4.Results / p20 (0024.jp2)
  27. 1)Antitumor effect on Ehrlich ascites carcinoma / p20 (0024.jp2)
  28. 2)Inhibitions of growth of 3LL by GIV-A and 5-FU / p20 (0024.jp2)
  29. 3)Additive effects of GIV-A and/or 5-FU on lung metastases / p24 (0028.jp2)
  30. 4)Direct cytocidal action of GIV-A on tumor cells / p24 (0028.jp2)
  31. 5)Effect of the antitumor agents on the phagocytic activity in EAC-bearing mice / p26 (0030.jp2)
  32. 6)Effects on the liver, spleen and thymus weights, number of spleen cells and QHS / p26 (0030.jp2)
  33. 7)Effect on phagocytosis of peritoneal macrophages / p29 (0033.jp2)
  34. 8)C3 converting activity in human serum / p29 (0033.jp2)
  35. 9)Effect on CL and C3 cleavage production of macrophages / p33 (0037.jp2)
  36. 10)Effects of GIV-A on peritoneal macrophages or lung macrophages and induction of C3-positive macrophages / p33 (0037.jp2)
  37. 11)Inhibitions of i.v. injection of peritoneal macrophages activated with GIV-A on lung metastases / p39 (0043.jp2)
  38. 12)Effects of GIV-A and/or 5-FU on PC-DTH / p41 (0045.jp2)
  39. 13)Flow cytometric analyses of splenic lymphocyte subsets / p41 (0045.jp2)
  40. 14)Effects of GIV-A on drug-metabolism in the liver of 3LL-bearing mice / p44 (0048.jp2)
  41. 15)Chemical analysis of antitumor active polysaccharides / p46 (0050.jp2)
  42. 4.Discussion / p52 (0056.jp2)
  43. 5.Conclusion / p61 (0065.jp2)
  44. 6.Acknowledgments / p63 (0067.jp2)
  45. 7.Abstract in Japanese / p64 (0068.jp2)
  46. 8.References / p67 (0071.jp2)
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各種コード

  • NII論文ID(NAID)
    500000130271
  • NII著者ID(NRID)
    • 8000000954038
  • DOI(NDL)
  • NDL書誌ID
    • 000000294585
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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