Pharmacokinetics of glycyrrhizin and Glycyrrhiza extract in normal rats with experimental acute hepatitis グリチルリチン及び甘草エキスのラットにおける体内動態と実験的急性肝炎時の変化

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著者

    • 王, 釗 オウ, ショウ

書誌事項

タイトル

Pharmacokinetics of glycyrrhizin and Glycyrrhiza extract in normal rats with experimental acute hepatitis

タイトル別名

グリチルリチン及び甘草エキスのラットにおける体内動態と実験的急性肝炎時の変化

著者名

王, 釗

著者別名

オウ, ショウ

学位授与大学

岡山大学

取得学位

博士 (薬学)

学位授与番号

甲第1501号

学位授与年月日

1996-03-25

注記・抄録

博士論文

目次

  1. CONTENTS / p3 (0004.jp2)
  2. SUMMARY / p1 (0003.jp2)
  3. INTRODUCTION / p6 (0006.jp2)
  4. Chapter 1 Gastrointestinal Absorption of Glycyrrhizin in Normal Rats / p10 (0008.jp2)
  5. Preface / p10 (0008.jp2)
  6. 1.Determination of Glycyrrhizin in Glycyrrhiza Extract / p13 (0009.jp2)
  7. 2.Stability of Glycyrrhizin in Artificial Gastric Juice,Rat Plasma,Rat Bile and Saline / p14 (0010.jp2)
  8. 3.Absorption of Glycyrrhiza Extract,Glycyrrhizin and Glycyrrhetic Acid by Loop Method in situ / p16 (0011.jp2)
  9. 4.Plasma Concentrations after Oral Administration of Glycyrrhiza Extract and Glycyrrhizin / p18 (0012.jp2)
  10. 5.Comparison of Gastrointestinal Transit of Glycyrrhiza Extract and Glycyrrhizin in Rats / p20 (0013.jp2)
  11. 6.Plasma Concentrations of Glycyrrhizin and Glycyrrhetic Acid after Intraduodenal Administration of Glycyrrhiza Extract / p24 (0015.jp2)
  12. 7.Recovery of Glycyrrhizin and Glycyrrhetic Acid after Intracecal Administration of Glycyrrhiza Extract and Glycyrrhizin / p24 (0015.jp2)
  13. 8.Pharmacokinetics of Glycyrrhizin and Glycyrrhetic Acid after Intravenous Administration / p26 (0016.jp2)
  14. 9.Interim Sum / p28 (0017.jp2)
  15. Chapter 2 Gastrointestinal Absorption in of Glycyrrhizin Pseudo-Bacteria-Free Rats and Bile-Fistula Rats / p31 (0018.jp2)
  16. 1.Hydrolysis of Drugs by Gastrointestinal Microflora / p31 (0018.jp2)
  17. 2.Plasma Concentrations after Oral Administration of Glycyrrhiza Extract and Glycyrrhizin in Pseudo-Bacteria-Free Rats / p35 (0020.jp2)
  18. 3.Plasma Kinetics and Biliary Elimination after Oral Administration of Glycyrrhiza Extract and Glycyrrhizin in Bile-Fistula Rats / p36 (0021.jp2)
  19. 4.Pharmacokinetics of Glycyrrhizin and Glycyrrhetic Acid after Intravenous Administration / p39 (0022.jp2)
  20. 5.Effects of Drugs on Bile Flow / p40 (0023.jp2)
  21. 6.Interim Sum / p42 (0024.jp2)
  22. Chapter 3 Effect of Deglycyrrhizin Glycyrrhiza Extract (DgGE)on Intestinal Absorption of Pure Glycyrrhizin / p45 (0025.jp2)
  23. 1.Preparation of DgGE / p45 (0025.jp2)
  24. 2.Effect of DgGE on Intestinal Absorption in situ / p47 (0026.jp2)
  25. 3.Effect of DgGE on Gastrointestinal Transit of Glycyrrhiza Extract and Glycyrrhizin in vivo / p48 (0027.jp2)
  26. 4.Effect of DgGE on Metabolism of Glycyrrhiza Extract and Glycyrrhizin by Gastrointestinal Microflora / p52 (0029.jp2)
  27. 5.Effect of DgGE on Pharmacokinetic Behaviors after Oral Administration of Glycyrrhiza Extract and Glycyrrhizin / p53 (0029.jp2)
  28. 6.Interim Sum / p58 (0032.jp2)
  29. Chapter 4 Gastrointestinal Absorption of Glycyrrhizin in Experimental Acute Hepatitis Model Rats Induced by D-Galactosamine (GAL Rats) / p60 (0033.jp2)
  30. 1.Preparation of GAL Rat / p61 (0033.jp2)
  31. 2.Plasma and Bile Kinetics after Oral Administration of Glycyrrhiza Extract and Glycyrrhizin in GAL Rat / p62 (0034.jp2)
  32. 3.Plasma and Bile Kinetics after Intravenous Administration of Glycyrrhizin in GAL Rat / p65 (0035.jp2)
  33. 4.Degradation of Glycyrrhizin and Glycyrrhetic Acid by Liver Homogenate of Normal and GAL Rats / p68 (0037.jp2)
  34. 5.Interim Sum / p70 (0038.jp2)
  35. ACKNOWLEDGEMENTS / p72 (0039.jp2)
  36. Chapter 5 Experimental Methods---1 / p73 (0039.jp2)
  37. 1.Materials / p73 (0039.jp2)
  38. 2.Animals / p73 (0039.jp2)
  39. 3.Preparation of Drug solution / p75 (0040.jp2)
  40. 4.Method of Oral,Intravenous,Intraduodenal and Intracecal Administrations of Drugs / p75 (0040.jp2)
  41. 5.Method of Sampling / p77 (0041.jp2)
  42. 6.Analytical Instruments and Methods / p77 (0041.jp2)
  43. 7.Pharmacokinetic Analysis / p78 (0042.jp2)
  44. Chapter 6 Experimental Methods---2 / p79 (0042.jp2)
  45. 1.In situ Stomach Pouch Method and Intestinal Loop Method / p79 (0042.jp2)
  46. 2.Cannulations of Bile Duct / p80 (0043.jp2)
  47. 3.Gastric Emptying and Intestinal Transit / p81 (0043.jp2)
  48. 4.Metabolism of Glycyrrhiza Extract and Glycyrrhizin by Gastrointestinal Bacteria / p81 (0043.jp2)
  49. 5.Degradation of Glycyrrhizin and Glycyrrhetic Acid by Liver Homogenate of Normal and GAL Rats / p81 (0043.jp2)
  50. REFERENCES / p83 (0044.jp2)
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各種コード

  • NII論文ID(NAID)
    500000130774
  • NII著者ID(NRID)
    • 8000000954511
  • DOI(NDL)
  • 本文言語コード
    • jpn
  • NDL書誌ID
    • 000000295088
  • データ提供元
    • 機関リポジトリ
    • NDL ONLINE
    • NDLデジタルコレクション

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