Analysis of subtle differences in structure of lysozyme : using monoclonal antibody and high resonance NMR spectroscopy リゾチームの微細な構造変化の解析 : モノクローナル抗体と高分解能NMRを用いて
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著者
書誌事項
- タイトル
-
Analysis of subtle differences in structure of lysozyme : using monoclonal antibody and high resonance NMR spectroscopy
- タイトル別名
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リゾチームの微細な構造変化の解析 : モノクローナル抗体と高分解能NMRを用いて
- 著者名
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阿部, 義人
- 著者別名
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アベ, ヨシト
- 学位授与大学
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九州大学
- 取得学位
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博士 (薬学)
- 学位授与番号
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甲第3715号
- 学位授与年月日
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1996-03-27
注記・抄録
博士論文
CHAPTER I Detection of Subtle Differences in the Surface Structure of Lysozymes by Use of an Immobilized Fab Fragment CHAPTER II Effect of Salt Concentration on the pKa of Acidic Residues in Lysozyme CHAPTER III Kinetically Trapped Structure in the Renaturation of Reduced Oxindolealanine 62 Lysozyme CHAPTER IV Reduction of Disulfide Bonds in Proteins by 2-Aminothiophenol under Weakly Acidic Conditions CHAPTER V Preparation of Lysozyme with ^13C Enriched Methionine Residues and Analysis of Its folded State in the Presence of Substrate Analog CHAPTER VI Identification of the Non-local Interaction in Denatured Hen Lysozyme CONCLUSION
目次
- CONTENTS / (0004.jp2)
- GENERAL INTRODUCTION / p1 (0005.jp2)
- CHAPTER I Detection of Subtle Differences in the Surface Structure of Lysozymes by Use of an Immobilized Fab Fragment / p4 (0006.jp2)
- CHAPTER II Effect of Salt Concentration on the pKa of Acidic Residues in Lysozyme / p22 (0015.jp2)
- CHAPTER III Kinetically Trapped Structure in the Renaturation of Reduced Oxindolealanine 62 Lysozyme / p40 (0024.jp2)
- CHAPTER IV Reduction of Disulfide Bonds in Proteins by 2-Aminothiophenol under Weakly Acidic Conditions / p63 (0036.jp2)
- CHAPTER V Preparation of Lysozyme with ¹³C Enriched Methionine Residues and Analysis of Its folded State in the Presence of Substrate Analog / p78 (0043.jp2)
- CHAPTER VI Identification of the Non-local Interaction in Denatured Hen Lysozyme / p98 (0053.jp2)
- CONCLUSION / p116 (0062.jp2)
- ACKNOWLEDGMENTS / p118 (0063.jp2)