Investigation on the transport mechanism of ceftibuten, a dianionic β-lactam model for the peptide-related compounds, across brush-border membranes from intestinal and renal epithelia ペプチド様ジアニオン型抗生物質セフチブテンの小腸および腎上皮細胞刷子縁膜透過機構に関する研究
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著者
書誌事項
- タイトル
-
Investigation on the transport mechanism of ceftibuten, a dianionic β-lactam model for the peptide-related compounds, across brush-border membranes from intestinal and renal epithelia
- タイトル別名
-
ペプチド様ジアニオン型抗生物質セフチブテンの小腸および腎上皮細胞刷子縁膜透過機構に関する研究
- 著者名
-
Naasani, Imad
- 著者別名
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ナサニ, イマド
- 学位授与大学
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北海道大学
- 取得学位
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博士 (薬学)
- 学位授与番号
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甲第3817号
- 学位授与年月日
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1996-03-25
注記・抄録
博士論文
目次
- Contents / (0005.jp2)
- List of Abbreviations / (0006.jp2)
- General Introduction / p1 (0007.jp2)
- References / p3 (0009.jp2)
- Part1:Studies with renal and intestinal brush-border membrane vesicles / p6 (0012.jp2)
- Chapter1:Transport mechanism of ceftibuten,a dianionic cephem,in rat renal brush-border membrane / p6 (0012.jp2)
- Introduction / p6 (0012.jp2)
- Materials and methods / p7 (0013.jp2)
- Results / p9 (0015.jp2)
- Discussion / p12 (0018.jp2)
- References / p13 (0019.jp2)
- Chapter2:Comparison of the transport characteristics of ceftibuten in rat renal and intestinal brush-border membranes / p15 (0021.jp2)
- Introduction / p15 (0021.jp2)
- Materials and methods / p16 (0022.jp2)
- Results / p17 (0023.jp2)
- Discussion / p26 (0032.jp2)
- References / p28 (0034.jp2)
- Part2:Studies with artificial membrane vesicles / p30 (0036.jp2)
- Chapter3:Solubilization and reconstitution characteristics of the carrier protein(s) responsible for the transport of ceftibuten,a substrate for the oligopeptide transporter,in rat renal brush-border membrane / p30 (0036.jp2)
- Introduction / p30 (0036.jp2)
- Materials and methods / p31 (0037.jp2)
- Results / p35 (0041.jp2)
- Discussion / p39 (0045.jp2)
- References / p43 (0049.jp2)
- Part3:A protocol for the purification of the carrier proteins / p45 (0051.jp2)
- Chapter4:Application of affinity chromatography to the purification of the carrier proteins responsible for the transport of ceftibuten in the brush-border membrane from rat renal proximal tubule / p45 (0051.jp2)
- Introduction / p45 (0051.jp2)
- Materials and methods / p45 (0051.jp2)
- Results and discussion / p50 (0056.jp2)
- References / p54 (0060.jp2)
- General Conclusions / p55 (0061.jp2)
- Abstract in Japanese / p56 (0062.jp2)
