Synthesis of polypeptides containing pyrenylalanines and characterization of the four α-helix bundle structure by the fluorescent probe ピレニルアラニン含有4α-ヘリックスバンドルポリペプチドの合成と蛍光プローブによる評価

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Title: Synthesis of polypeptides containing pyrenylalanines and characterization of the four α-helix bundle structure by the fluorescent probe

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CONTENTS / (0003.jp2)
Introduction. / p1 (0005.jp2)
Chapter 1.Design and Synthesis of Four α-Helix Bundle Polypeptide Containing 1-Pyrenylalanines as Fluorescenct Probe. / p5 (0007.jp2)
1-1.Introduction. / p5 (0007.jp2)
1-2.Results and Discussion. / p5 (0007.jp2)
1-3.Experimental. / p15 (0012.jp2)
Chapter 2.Characterization of Designed Four α-Helix Bundle Polypeptide with a Pair of Pyrene Groups. / p22 (0016.jp2)
2-1.Introduction. / p22 (0016.jp2)
2-2.Results and Discussion. / p22 (0016.jp2)
2-3.Experimental. / p33 (0021.jp2)
Chapter 3.Stabilization of Four α-Helix Bundle Conformation with Elongation of β-Turn Parts. / p38 (0024.jp2)
3-1.Introduction. / p38 (0024.jp2)
3-2.Results and Discussion. / p38 (0024.jp2)
3-3.Experimental. / p45 (0027.jp2)
Chapter 4.Design and Synthesis of a New Four α-Helix Bundle Polypeptide Connnecting D- and L-Segments. / p46 (0028.jp2)
4-1.Introduction. / p46 (0028.jp2)
4-2.Results and Discussion. / p46 (0028.jp2)
4-3.Experimental. / p49 (0029.jp2)
Chapter 5.Fluorescence Energy Transfer from Pyrene Excimer in 53-Peptide to Alkyl Acridine Oranges. / p56 (0033.jp2)
5-1.Introduction. / p56 (0033.jp2)
5-2.Results and Discussion. / p56 (0033.jp2)
5-3.Experimental. / p63 (0036.jp2)
Summary. / p65 (0037.jp2)
Acknowledments. / p66 (0038.jp2)
References. / p67 (0038.jp2)
List of Publications. / p69 (0039.jp2)

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