Evaluation of stereoselective cutaneous hydrolysis and transdermal delivery of propranolol prodrugs プロプラノロールプロドラッグの立体選択的加水分解特性と経皮吸収性の評価
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著者
書誌事項
- タイトル
-
Evaluation of stereoselective cutaneous hydrolysis and transdermal delivery of propranolol prodrugs
- タイトル別名
-
プロプラノロールプロドラッグの立体選択的加水分解特性と経皮吸収性の評価
- 著者名
-
Shamim Ahmed
- 著者別名
-
シャーミム アハメッド
- 学位授与大学
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熊本大学
- 取得学位
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博士 (薬学)
- 学位授与番号
-
甲第42号
- 学位授与年月日
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1996-03-26
注記・抄録
博士論文
目次
- Contents / (0005.jp2)
- Chapter1 General Introduction / p1 (0007.jp2)
- 1.1 Transdermal Drug Delivery / p1 (0007.jp2)
- 1.2 Stereoselective Studies / p7 (0010.jp2)
- 1.3 Propranolol:Transdermal Delivery and Stereoselectivity / p8 (0011.jp2)
- 1.4 Purpose of This Thesis / p10 (0012.jp2)
- Chapter2 Design of Prodrug:Synthesis and Physicochemical Studies / p12 (0013.jp2)
- 2.1 Introduction / p12 (0013.jp2)
- 2.2 Results and Discussion / p12 (0013.jp2)
- 2.3 Summary / p16 (0015.jp2)
- Chapter3 Stereoselective Hydrolysis Studies of Propranolol Prodrugs in Hairless Mouse Skin,Liver and Plasma:Evaluation of Skin Activity and Esterase Nature / p17 (0015.jp2)
- 3.1 Introduction / p17 (0015.jp2)
- 3.2 Results and Discussion / p17 (0015.jp2)
- 3.3 Summary / p26 (0020.jp2)
- Chapter4 Stereoselective Permeation and Concurrent Cutaneous Hydrolysis of Prodrugs Across Hairless Mouse Skin / p28 (0021.jp2)
- 4.1 Introduction / p28 (0021.jp2)
- 4.2 Results and Discussion / p29 (0021.jp2)
- 4.3 Summary / p42 (0028.jp2)
- Chapter5 Further Evidences to Support the Proposed Mechanism of Stereoselective Permeation / p44 (0029.jp2)
- 5.1 Introduction / p44 (0029.jp2)
- 5.2 Results and Discussion / p45 (0029.jp2)
- 5.3 Summary / p55 (0034.jp2)
- Chapter6 Skin Irritation Test / p57 (0035.jp2)
- 6.1 Introduction / p57 (0035.jp2)
- 6.2 Results and Discussion / p57 (0035.jp2)
- 6.3 Summary / p59 (0036.jp2)
- Chapter7 Experimental Section / p60 (0037.jp2)
- Summary / p69 (0041.jp2)
- Concluding Remarks / p72 (0043.jp2)
- Acknowledgments / p73 (0043.jp2)
- References / p74 (0044.jp2)