Muscarinic M[1] and M[2] subtype-specific regulation of cardiac automaticity :functional cross-talk with β-adrenergic receptor signaling cascade 心筋の自動能に対するムスカリン受容体M[1], M[2]サブタイプの制御 : β-アドレナリン性情報伝達系との相互作用
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著者
書誌事項
- タイトル
-
Muscarinic M[1] and M[2] subtype-specific regulation of cardiac automaticity :functional cross-talk with β-adrenergic receptor signaling cascade
- タイトル別名
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心筋の自動能に対するムスカリン受容体M[1], M[2]サブタイプの制御 : β-アドレナリン性情報伝達系との相互作用
- 著者名
-
Islam, Md. Amirul
- 著者別名
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イスラム, エムディー アミール
- 学位授与大学
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富山医科薬科大学
- 取得学位
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博士 (薬学)
- 学位授与番号
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甲第309号
- 学位授与年月日
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1998-03-10
注記・抄録
博士論文
目次
- Contents / p1 (0005.jp2)
- Abstract / p4 (0008.jp2)
- Introduction / p1 (0011.jp2)
- Chapter1 Background and aim of the study / p3 (0013.jp2)
- 1.1.Muscarinic and β-adrenergic regulation of cardiac activity / p3 (0013.jp2)
- 1.2.Muscarinic and β-adrenergic effects of aconitine and higenamine- two cardioactive principles from aconite root / p7 (0017.jp2)
- 1.3.Aim and rationale of the present study / p8 (0018.jp2)
- Chapter2 Cholera toxin accentuates the antagonism by acetylcholine of β-adrenergic activation-induced positive chronotropy in isolated right atria of mice / p10 (0020.jp2)
- 2.1.Materials and Methods / p10 (0020.jp2)
- 2.2.Results / p11 (0021.jp2)
- 2.3.Discussion / p14 (0024.jp2)
- 2.4.Summary / p17 (0027.jp2)
- 2.5.Conclusion / p17 (0027.jp2)
- Chapter3 Potentiation by higenamine of the aconitine-induced positive chronotropic effect in isolated right atria of mice: The effects of cholera toxin, forskolin and pertussis toxin / p18 (0028.jp2)
- 3.1.Materials and Methods / p18 (0028.jp2)
- 3.2.Results / p19 (0029.jp2)
- 3.3.Discussion / p24 (0034.jp2)
- 3.4.Summary / p26 (0036.jp2)
- 3.5.Conclusion / p27 (0037.jp2)
- Chapter4 Muscarinic M₁ receptor activation reduces the maximum upstroke velocity of action potential in mouse isolated right atria / p28 (0038.jp2)
- 4.1.Materials and methods / p28 (0038.jp2)
- 4.2.Results / p30 (0040.jp2)
- 4.3.Discussion / p36 (0046.jp2)
- 4.4.Summary / p40 (0050.jp2)
- 4.5.Conclusion / p41 (0051.jp2)
- Chapter5 Acetylcholine-induced biphasic effect on the maximum upstroke velocity of action potential in mouse isolated right atria: Interaction with β-adrenergic signaling cascade / p42 (0052.jp2)
- 5.1.Materials and methods / p42 (0052.jp2)
- 5.2.Results / p43 (0053.jp2)
- 5.3.Discussion / p50 (0060.jp2)
- 5.4.Summary / p52 (0062.jp2)
- 5.5.Conclusion / p52 (0062.jp2)
- Chapter6 Age related alterations in muscarinic M₁ and M₂ receptor-mediated effects on action potential in mice right atria / p53 (0063.jp2)
- 6.1.Materials and methods / p53 (0063.jp2)
- 6.2.Results / p54 (0064.jp2)
- 6.3.Discussion / p56 (0066.jp2)
- 6.4.Summary / p57 (0067.jp2)
- 6.5.Conclusion / p58 (0068.jp2)
- Chapter7 Genrral Discussion / p59 (0069.jp2)
- Conclusion / p63 (0073.jp2)
- References / p65 (0075.jp2)
- Appendix / p74 (0084.jp2)