High resolution solution NMR structure of the Z-domain of staphylococcal protein A and its initial binding study with immunoglobulin G

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タイトル: High resolution solution NMR structure of the Z-domain of staphylococcal protein A and its initial binding study with immunoglobulin G

タイトル別名: 異種核相関核磁気共鳴スペクトルによるStaphylococcal Protein Aの水溶液中における三次元構造の決定と免疫グロブリンとの結合に関する研究

博士論文

TABLE OF CONTENTS / (0004.jp2)
CHAPTER1:Introduction / p1 (0006.jp2)
1-A Recent developments of multidimensional NMR techniques for structure determination of proteins / p1 (0006.jp2)
1-B The Z-domain of staphylococcal protein A / p3 (0008.jp2)
CHAPTER2:Development of novel triple resonance NMR techniques for the sequential assignments of staphylococcal protein A Z-domain / p6 (0011.jp2)
2-A Development of HCC(CO)NH-TOCSY experiment for the sequential assignments of staphylococcal protein A Z-domain / p6 (0011.jp2)
2-B Classification of amino acid spin systems using pulsed-field gradient HCC(CO)NH-TOCSY with constant-time aliphatic ¹³C frequency labeling / p14 (0019.jp2)
2-C Phase labeling of C-H and C-C spin-system topologies:application to constant-time PFG-CBCA(CO)NH experiments for discriminating amino-acid spin-system topologies / p23 (0028.jp2)
2-D ¹H,¹³C,and ¹⁵N assignments of staphylococcal protein A Z-domain / p35 (0040.jp2)
CHAPTER3:Determination of the solution NMR structure of staphylococcal protein A Z-domain / p42 (0047.jp2)
3-A The secondary structure analysis of Z-domain / p42 (0047.jp2)
3-B Structure calculation of Z-domain / p46 (0051.jp2)
3-C Three dimensional structure of Z-domain / p50 (0055.jp2)
3-D ¹H/²H exchange experiment of Z-domain free,and bound to immunoglobulin G / p53 (0058.jp2)
CHAPTER4:Conclusion / p59 (0064.jp2)
Acknowledgement / p60 (0065.jp2)
References / p61 (0066.jp2)
Appendix / p65 (0070.jp2)