Structural studies on the interactions of aureoic acid family antitumor antibiotics with DNA オーレオリック酸類抗癌剤とDNAとの相互作用の構造研究
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Bibliographic Information
- Title
-
Structural studies on the interactions of aureoic acid family antitumor antibiotics with DNA
- Other Title
-
オーレオリック酸類抗癌剤とDNAとの相互作用の構造研究
- Author
-
片平, 律子
- Author(Another name)
-
カタヒラ, リツコ
- University
-
大阪大学
- Types of degree
-
博士(理学)
- Grant ID
-
乙第7597号
- Degree year
-
1998-09-30
Note and Description
博士論文
Table of Contents
- Contents / (0003.jp2)
- Chapter 1.General Introduction / p1 (0004.jp2)
- 1-1.The aim of this thesis / p2 (0005.jp2)
- 1-2.DNA-drug interactions / p2 (0005.jp2)
- 1-2.Aureolic acid compounds / p5 (0007.jp2)
- 1-3.Conformation of DNA / p7 (0008.jp2)
- 1-4.NMR / p11 (0010.jp2)
- 1-5.DNA unwinding / p18 (0014.jp2)
- Chapter 2.Novel Antitumor Drug, UCH9 / p21 (0015.jp2)
- 2-1.Introduction / p22 (0016.jp2)
- 2-2.Materials and Methods / p23 (0016.jp2)
- 2-3.Results / p25 (0017.jp2)
- 2-4.Discussion / p38 (0024.jp2)
- Chapter 3.DNA Unwindg Assay of Aureolic Acid Compounds / p40 (0025.jp2)
- 3-1.Introduction / p41 (0025.jp2)
- 3-2.Materials and Methods / p43 (0026.jp2)
- 3-3.Results and Discussion / p44 (0027.jp2)
- Chapter 4.Photo-CIDNP Experiment / p49 (0029.jp2)
- 4-1.Introduction / p50 (0030.jp2)
- 4-2.Materials and Methods / p51 (0030.jp2)
- 4-3.Results / p51 (0030.jp2)
- 4-4.Discussion / p58 (0034.jp2)
- Chapter 5.Structure Analysis of Free d(GGGGCCCC)₂ and the ChromomycinA₃-d(GGGGCCCC)₂ Complex by NMR / p63 (0036.jp2)
- 5-1.Introduction / p64 (0037.jp2)
- 5-2.Materials and Methods / p65 (0037.jp2)
- 5-3.Results / p67 (0038.jp2)
- 5-4.Discussion / p80 (0045.jp2)
- Chapter 6.Structure Determination of UCH9-d(TTGGCCAA)₂ Complex by NMR / p93 (0052.jp2)
- 6-1.Introduction / p94 (0052.jp2)
- 6-2.Materials and Methods / p97 (0054.jp2)
- 6-3.Results / p99 (0055.jp2)
- 6-4.Discussion / p115 (0063.jp2)
- General Discussion and Conclusion / p125 (0069.jp2)
- List of publications / p130 (0072.jp2)
- Acknowledgements / p132 (0073.jp2)