Functional analysis of TGF-β-activated kinase 1(TAK1) in Drosophila ショウジョウバエを用いたTGF-β-activated kinase 1(TAK1)の機能解析
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著者
書誌事項
- タイトル
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Functional analysis of TGF-β-activated kinase 1(TAK1) in Drosophila
- タイトル別名
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ショウジョウバエを用いたTGF-β-activated kinase 1(TAK1)の機能解析
- 著者名
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高津, 吉広
- 著者別名
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タカツ, ヨシヒロ
- 学位授与大学
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北海道大学
- 取得学位
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博士(薬学)
- 学位授与番号
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甲第4723号
- 学位授与年月日
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1999-03-25
注記・抄録
博士論文
目次
- 1. INTRODUCTION / p3 (0006.jp2)
- 2. MATERIALS and METHODS / p10 (0013.jp2)
- 2-1. Expression systems of transgenes / p10 (0013.jp2)
- 2-2. Plasmid construction and generation of transgenic flies / p10 (0013.jp2)
- 2-3. Fly culture and genetic screen / p14 (0017.jp2)
- 2-4. Histology / p15 (0018.jp2)
- 2-5. Phosphorylation analysis / p16 (0019.jp2)
- 3. FUNCTIONAL ANALYSIS of mTAK1 / p17 (0020.jp2)
- 3-1.Ectopic expression of mTAK1 resulted in various defects in adult tissues and lethality in early developmental stages / p17 (0020.jp2)
- 3-2. Ectopic expression of mTAK1 in visual system resulted in the reduced eye phenotype / p17 (0020.jp2)
- 3-3. Coexpression of hTAB1 with mTAK1 enhanced the reduced eye phenotype by mTAK1 / p23 (0026.jp2)
- 3-4. Ectopically activated TAK1 signaling induced apoptosis in the eyes / p23 (0026.jp2)
- 3-5. Ectopically activated TAK1 signaling affected the cell shape in the eyes / p27 (0030.jp2)
- 3-6. Loss-of-function phenotype using a dominant negative mutant of mTAK1 / p29 (0032.jp2)
- 3-7 TAK1 specifically activates Hep-Bsk cascade / p32 (0035.jp2)
- 4. COMPARISON BETWEEN DTAK1 and mTAK1 / p41 (0044.jp2)
- 4-1. DTAK1 is a structural homolog of mTAK1 / p41 (0044.jp2)
- 4-2. DTAK1 is a functional homolog of mTAK1 / p41 (0044.jp2)
- 4-3. The TAK1 signaling facilitated apoptosis through the induction of rpr and hid / p44 (0047.jp2)
- 5. DISCUSSION / p53 (0056.jp2)
- 5-1. Signal specificity of TAK1 for the MAPK pathways in vivo / p53 (0056.jp2)
- 5-2. Endogenous function of the TAK1 signaling / p55 (0058.jp2)
- 5-3. TAK1 doesn't function in the TGF-β/Dpp signaling / p55 (0058.jp2)
- 5-4. Apoptosis triggered by TAK1-JNK signaling pathway / p56 (0059.jp2)
- 5-5. Perspective / p59 (0062.jp2)
- 6. SUMMARY / p61 (0064.jp2)
- 7. REFERENCES / p63 (0066.jp2)
- 8. ACKNOWLEDGMENTS / p69 (0072.jp2)