Design and syntheses of peptide zinc complexes and their catalytic function on phosphoesters ペプチド亜鉛錯体の設計と合成およびリン酸エステルに対する触媒機能

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著者

    • Md. Khabir Uddin モハメッド カビル ウッディン

書誌事項

タイトル

Design and syntheses of peptide zinc complexes and their catalytic function on phosphoesters

タイトル別名

ペプチド亜鉛錯体の設計と合成およびリン酸エステルに対する触媒機能

著者名

Md. Khabir Uddin

著者別名

モハメッド カビル ウッディン

学位授与大学

北海道大学

取得学位

博士(地球環境科学)

学位授与番号

甲第4894号

学位授与年月日

1999-03-25

注記・抄録

博士論文

目次

  1. Table of Contents / (0004.jp2)
  2. Abbreviations / p1 (0006.jp2)
  3. Chapter1.Introduction. / (0007.jp2)
  4. 1.1.Histidine-containing zinc enzyme in native system. / p3 (0008.jp2)
  5. 1.2.Active site of alkaline phosphatase and its reaction mechanism with phosphoesters. / p4 (0009.jp2)
  6. 1.3.Zinc-containing artificial enzymes and their reaction mechanism with substrate. / p7 (0012.jp2)
  7. 1.4.Objects and perspective of the present study. / p10 (0015.jp2)
  8. 1.5.References. / p11 (0016.jp2)
  9. Chapter2.Design and syntheses of peptides as ligands. / (0019.jp2)
  10. 2.1.Methods of peptide synthesis. / p15 (0020.jp2)
  11. 2.2.Design of ligands / p16 (0021.jp2)
  12. 2.3.Synthesis of N,N'-dihistidylethylenediamine L1. / p19 (0024.jp2)
  13. 2.4.Synthesis of im-bzl-N,N"-dihistidyldiethylenetriamine L2 / p23 (0028.jp2)
  14. 2.5.Synthesis of L-His-L-His-L-His-L-Tyr-L-His-L-His-L-His L3. / p28 (0033.jp2)
  15. 2.6.References. / p38 (0043.jp2)
  16. Chapter3.Potentiometric titration of the ligands and with zinc in aqueous solution. / (0044.jp2)
  17. 3.1.General method and materials / p40 (0045.jp2)
  18. 3.2.pH titration of L1 and its pKa values. / p41 (0046.jp2)
  19. 3.3.pH titration of L2 and equimolar zinc solution and their pKa and Kst values. / p43 (0048.jp2)
  20. 3.4.Distribution curves of chemical species in aqueous solution of zinc complex of L2. / p53 (0058.jp2)
  21. 3.5.pH titration of L3 and its pKa values. / p55 (0060.jp2)
  22. 3.6.Discussion. / p57 (0062.jp2)
  23. 3.7.References. / p57 (0062.jp2)
  24. Chapter4.Zinc titration. / (0063.jp2)
  25. 4.1.General methods / p59 (0064.jp2)
  26. 4.2.Zinc titration for aqueous solution of L1 or L2 using ¹H NMR technique. / p59 (0064.jp2)
  27. 4.3.Zinc titration for aqueous solution of L3 using ¹H NMR technique. / p61 (0066.jp2)
  28. 4.4.Discussion. / p62 (0067.jp2)
  29. 4.5.References. / p64 (0069.jp2)
  30. Chapter5.Syntheses of zinc complexes. / (0070.jp2)
  31. 5.1.General method / p66 (0071.jp2)
  32. 5.2.Synthesis of zinc complex 1 of L1. / p66 (0071.jp2)
  33. 5.3.Determination of the compositions of complexes 2 and 3 / p67 (0072.jp2)
  34. 5.4.Discussion. / p68 (0073.jp2)
  35. 5.5.References. / p69 (0074.jp2)
  36. Chapter6.Hydrolyses of phosphate esters using zinc complexes as catalysts. / (0075.jp2)
  37. 6.1.Catalytic activities of complexes 1,2 and 3 on bis(p-nitrophenyl)phosphate(BNPP)and p-nitrophenyl phosphate(NPP). / p71 (0076.jp2)
  38. 6.2.pH dependence of hydrolysis rate constants of BNPP. / p74 (0079.jp2)
  39. 6.3.Temperature dependence of hydrolysis rate constants of BNPP. / p75 (0080.jp2)
  40. 6.4.Discussion. / p76 (0081.jp2)
  41. 6.5.References. / p78 (0083.jp2)
  42. Chapter7.Summary and Conclusions. / p80 (0085.jp2)
  43. Zinc Complexes of Artificial Histidine-containing Dipeptides as Catalysts of Hydrolyses of p-Nitrophenyl Phosphates / p115 (0090.jp2)
  44. CO₂ Hydration by Mimic Zinc Complex for Active Site of Carbonic Anhydrase / p991 (0092.jp2)
  45. Methylene chain length and coordination geometry in triosmium clusters containing diphosphine ligands X-Ray crystal structures of 〔Os₃(CO)₁₀{μ-Ph₂P(CH₂)nPPh₂}〕(n=4or5) and 〔Os₃(CO)₈{μ-Ph₂PCH₂PPh₂}₂〕 / p41 (0094.jp2)
  46. Protonation of diphosphine and phosphite derivatives of dodecacarbonyltriruthenium / p121 (0105.jp2)
  47. SYNTHESIS AND DYNAMIC BEHAVIOUR OF〔Ru₃(CO)₁₀{P(OMe)₃}₂〕 / p87 (0111.jp2)
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各種コード

  • NII論文ID(NAID)
    500000172452
  • NII著者ID(NRID)
    • 8000000172727
  • DOI(NDL)
  • NDL書誌ID
    • 000000336766
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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