Modifications of μ-opioid receptor agonist-induced several pharmacological actions by diabetes in mice : possible involvement of protein kinase C and intracellular calcium
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著者
書誌事項
- タイトル
-
Modifications of μ-opioid receptor agonist-induced several pharmacological actions by diabetes in mice : possible involvement of protein kinase C and intracellular calcium
- 著者名
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大澤, 匡弘
- 著者別名
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オオサワ, マサヒロ
- 学位授与大学
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星薬科大学
- 取得学位
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博士(薬学)
- 学位授与番号
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甲第72号
- 学位授与年月日
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1999-03-13
注記・抄録
博士論文
1998年度
目次
- Table of Contents / (0004.jp2)
- General Introduction / p1 (0006.jp2)
- Chapter1 Modification of μ-opioid receptor-mediated pharmacological action by diabetes in mice:possible involvement of protein kinase C and intracellular calcium / p12 (0012.jp2)
- Introduction / p13 (0013.jp2)
- Experiment1-1:Effects of diabetes on the morphine-induced Straub tail reaction in mice. / p16 (0014.jp2)
- Experiment1-2:Possible involvement of protein kinase C in the attenuation of the morphine-induced Straub tail reaction in diabetic mice / p20 (0016.jp2)
- Experiment1-3:Possible involvement of protein kinase C in the attenuation of DAMGO-induced antinociception in diabetic mice. / p26 (0019.jp2)
- Experiment1-4:Role of intracellular calcium in modification of μ- and δ-opioid receptor-mediated antinociception by diabetes in mice. / p34 (0023.jp2)
- Discussion / p46 (0029.jp2)
- Chapter2 Modification of naloxone-precipitated withdrawal syndrome by diabetes in mice:possible involvement of protein kinase C and intracellular calcium / p54 (0033.jp2)
- Introduction / p55 (0034.jp2)
- Experiment2-1:Modification of development of morphine dependence by diabetes / p61 (0037.jp2)
- Experiment2-2:Effect of diabetes on the morphine-induced inhibition of gastrointestinal transit. / p68 (0040.jp2)
- Experiment2-3:Role of noradrenergic functions in the modification of naloxone-precipitated withdrawal jumping in morphine-dependent mice by diabetes / p73 (0043.jp2)
- Experiment2-4:Modification of the expression of naloxone-precipitated withdrawal signs in morphine-dependent mice by diabetes:possible involvement of protein kinase C. / p78 (0046.jp2)
- Experiment2-5:Role of intracellular calcium on the modulation of naloxone-precipitated withdrawal jumping in morphine-dependent mice by diabetes. / p89 (0051.jp2)
- Discussion / p96 (0055.jp2)
- Chapter3 Modification of reinforcing effect of several addictive drugs by diabetes in mice / p106 (0060.jp2)
- Introduction / p107 (0061.jp2)
- Experiment3-1:Modification of morphine-induced place preference by diabetes / p111 (0063.jp2)
- Experiment3-2:Effects of diabetes on methamphetamine-induced place preference in mice. / p123 (0069.jp2)
- Experiment3-3:Effects of streptozotocin-induced diabetes on place conditioning action of cocaine in mice / p131 (0073.jp2)
- Discussion / p135 (0075.jp2)
- Conclusion / p142 (0078.jp2)
- Acknowledgements / p147 (0081.jp2)
- References / p148 (0081.jp2)