Insulin delivery system for subcutaneous and mucosal administratoin

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著者

    • José Mario Barichello ジョゼ マリオ バリチェロ

書誌事項

タイトル

Insulin delivery system for subcutaneous and mucosal administratoin

著者名

José Mario Barichello

著者別名

ジョゼ マリオ バリチェロ

学位授与大学

星薬科大学

取得学位

博士(薬学)

学位授与番号

甲第74号

学位授与年月日

1999-03-13

注記・抄録

博士論文

目次

  1. CONTENTS / p1 (0003.jp2)
  2. GENERAL INTRODUCTION / p1 (0005.jp2)
  3. CHAPTER1.Encapsulation of Hydrophilic and Lipophilic Drugs in PLGA Nanoparticles by the Nanoprecipitation Method / p6 (0008.jp2)
  4. I.Introduction / p7 (0009.jp2)
  5. II.Characteristics of Particle Size / p8 (0009.jp2)
  6. III.Characteristics of Drug Loading / p9 (0010.jp2)
  7. IV.In situ Absorption Experiments / p12 (0011.jp2)
  8. V.Summary / p14 (0012.jp2)
  9. VI.Experimental Section / p14 (0012.jp2)
  10. CHAPTER2.Absorption of Insulin from Pluronic F-127 Gels Following Subcutaneous Administration in Rats / p19 (0015.jp2)
  11. I.Introduction / p20 (0016.jp2)
  12. II.In vitro Insulin Release from PF127 Gel Formulations / p21 (0016.jp2)
  13. III.Changes in Serum Insulin and Glucose Levels Following Subcutaneous Administration of an Insulin Solution / p25 (0018.jp2)
  14. IV.Changes in Serum Insulin and Glucose Levels Following Subcutaneous Administration of an INP Formulation / p26 (0019.jp2)
  15. V.Changes in Serum Insulin and Glucose Levels Following Subcutaneous Administration of Insulin-loaded PF127 Gels / p28 (0020.jp2)
  16. VI.Changes in Serum Insulin and Glucose Levels Following Subcutaneous Administration of INP-loaded PF127 Gels / p29 (0020.jp2)
  17. VII.Statistical Analysis of the Area Under the Curve of the Serum Glucose Levels(AUCglu)of the Various Insulin Formulations / p30 (0021.jp2)
  18. VIII.Pharmacokinetic Parameters of Insulin Following Subcutaneous Administration of the Various Formulations / p31 (0021.jp2)
  19. IX.Summary / p32 (0022.jp2)
  20. X.Experimental Section / p34 (0023.jp2)
  21. CHAPTER3.Enhanced Rectal Absorption of Insulin-loaded PF127 Gels Containing Unsaturated Fatty Acids / p38 (0025.jp2)
  22. I.Introduction / p39 (0026.jp2)
  23. II.Changes in Serum Insulin and Glucose Levels Following Rectal Administration of an Insulin-loaded PF127 Gel Formulation / p40 (0026.jp2)
  24. III.Changes in Serum Insulin and Glucose Levels Following Rectal Administration of Various Insulin-loaded PF127 Gel Formulations Containing Unsaturated Fatty Acids / p42 (0027.jp2)
  25. IV.Pharmacokinetic Parameters of Insulin Following Rectal Administration of Various PF127 Gel Formulations Containing Different Unsaturated Fatty Acids / p46 (0029.jp2)
  26. V.Hypoglycemic Efficacy Relative to Subcutaneous Administration / p47 (0030.jp2)
  27. VI.Summary / p49 (0031.jp2)
  28. VII.Experimental Section / p49 (0031.jp2)
  29. SUMMARY / p53 (0033.jp2)
  30. CONCLUSIONS / p54 (0034.jp2)
  31. ACKNOWLEDGMENTS / p55 (0035.jp2)
  32. REFERENCES / p56 (0036.jp2)
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各種コード

  • NII論文ID(NAID)
    500000172586
  • NII著者ID(NRID)
    • 8000000172862
  • DOI(NDL)
  • NDL書誌ID
    • 000000336900
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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