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Interleukin-6 functions as an autocrine invasion factor of human pancreatic cancer cells (in vitro) インターロイキン6はヒト膵癌細胞の自己産生の浸潤誘導物質として作用する

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著者

    • 井出澤, 剛直 イデザワ, タケナオ

書誌事項

タイトル

Interleukin-6 functions as an autocrine invasion factor of human pancreatic cancer cells (in vitro)

タイトル別名

インターロイキン6はヒト膵癌細胞の自己産生の浸潤誘導物質として作用する

著者名

井出澤, 剛直

著者別名

イデザワ, タケナオ

学位授与大学

山梨医科大学

取得学位

博士(医学)

学位授与番号

甲第199号

学位授与年月日

1999-03-24

注記・抄録

博士論文

目次

  1. CONTENTS / p1 (0002.jp2)
  2. ABSTRACT / p5 (0006.jp2)
  3. INTRODUCTION / p8 (0009.jp2)
  4. MATERIALS AND METHODS / p11 (0012.jp2)
  5. 1.Cells and cell culture / p11 (0012.jp2)
  6. 2.Invasion assay / p11 (0012.jp2)
  7. 3.Effect of IL-6 on invasive ability of PSN-1 cells / p12 (0013.jp2)
  8. 4.Separation of PSN-1 cells by chemoinvasion assay in the presence of IL-6 / p13 (0014.jp2)
  9. 5.Effect of IL-6 on 5H and 5L cells / (0016.jp2)
  10. 6.Preparation of cancer cell-derived conditioned medium / p16 (0017.jp2)
  11. 7.Expression of IL-6 receptor on 5H and 5L cells / p20 (0021.jp2)
  12. 8.Statistical analysis / p20 (0021.jp2)
  13. RESULTS / p21 (0022.jp2)
  14. 1.Effect of IL-6 on invasive ability of PSN-1 cells / p21 (0022.jp2)
  15. 2.Establishment of two clones from PSN-1 cells by chemoinvasion assay in the presence of IL-6 / p22 (0023.jp2)
  16. 3.Effect of IL-6 on 5H and 5L cells / p23 (0024.jp2)
  17. 4.Effect of HCM on 5H and 5L cells / p23 (0024.jp2)
  18. 5.Effect of anti-IL-6 antibody treated HCM on invasive ability of 5H cells / p24 (0025.jp2)
  19. 6.Expression of IL-6 receptor on 5H and 5L cells / p25 (0026.jp2)
  20. DISCUSSION / p26 (0027.jp2)
  21. REFERENCES / p32 (0033.jp2)
  22. TABLE AND FIGURES / p36 (0037.jp2)
  23. Table 1.Effect of IL-6 on invasive ability of PSN-1 cells / p37 (0038.jp2)
  24. Figure 1.Establishment of two clones from PSN-1 cells by chemoinvasion assay in the presence of IL-6 / p38 (0039.jp2)
  25. Figure 2a.Appearance of 5H cells / p39 (0040.jp2)
  26. Figure 2b.Appearance of 5L cells / p40 (0041.jp2)
  27. Figure 3.Proliferation assay of 5H and 5L cells / p41 (0042.jp2)
  28. Figure 4.Level of IL-6 in HCM and LCM / p42 (0043.jp2)
  29. Figure 5.Invasion assay of 5H and 5L cells / p43 (0044.jp2)
  30. Figure 6.Effect of IL-6 on invasive ability of 5H and 5L cells / p44 (0045.jp2)
  31. Figure 7.Morphology of 5H and 5L cells after addition of IL-6. / p45 (0046.jp2)
  32. Figure 8.Effect of HCM and LCM on invasive ability of 5H and 5L cells / p46 (0047.jp2)
  33. Figure 9a.Morphology of 5L cells before addition of HCM / p47 (0048.jp2)
  34. Figure 9b.Morphological change of 5L cells after addition of HC / p48 (0049.jp2)
  35. Figure 10.Proliferation assay of 5H and 5L cells with HCM / p49 (0050.jp2)
  36. Figure 11.Level of IL-6 in anti-IL-6 antibody treated HCM / p50 (0051.jp2)
  37. Figure 12.Effect of anti-IL-6 antibody treated HCM on invasive ability of 5H cells / p51 (0052.jp2)
  38. Figure 13.Expression of IL-6 receptor on 5H and 5L cells / p52 (0053.jp2)
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各種コード

  • NII論文ID(NAID)
    500000173464
  • NII著者ID(NRID)
    • 8000000173740
  • DOI(NDL)
  • NDL書誌ID
    • 000000337778
  • データ提供元
    • NDL-OPAC
    • NDLデジタルコレクション
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