Effect of renal dysfunction on the pharmacokinetics and pharmacodynamics of centrally acting drugs : a study with electroencephalography
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著者
書誌事項
- タイトル
-
Effect of renal dysfunction on the pharmacokinetics and pharmacodynamics of centrally acting drugs : a study with electroencephalography
- 著者名
-
Kalpana Srivastava
- 著者別名
-
カラパナ シリバスターバ
- 学位授与大学
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富山医科薬科大学
- 取得学位
-
博士(薬学)
- 学位授与番号
-
甲第347号
- 学位授与年月日
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1999-03-10
注記・抄録
博士論文
目次
- Acknowledgement / p1 (0004.jp2)
- List of abbreviations / p2 (0005.jp2)
- Contents / p3 (0006.jp2)
- General Introduction / p1 (0008.jp2)
- Chapter1 Validity of the quantitative EEG method as the surrogate measure of pharmacological response in single and combined drug administration / p6 (0013.jp2)
- 1.1. Introduction / p7 (0014.jp2)
- 1.2. Materials and methods / p7 (0014.jp2)
- 1.3. EEG effect of oxazepam / p15 (0022.jp2)
- 1.4. EEG effect of thiopental / p19 (0026.jp2)
- 1.5. Combined EEG effect of oxazepam and flumazenil / p25 (0032.jp2)
- 1.6. Combined EEG effect of oxazepam and thiopental / p29 (0036.jp2)
- 1.7. Conclusion / p30 (0037.jp2)
- Chapter2 Application of EEG method in disease condition:pharmacokinetic and pharmacodynamic studies of centrally acting drugs in renal dysfunction / p31 (0038.jp2)
- 2.1. Introduction / p32 (0039.jp2)
- 2.2. Materials and methods / p32 (0039.jp2)
- 2.3. Pharmacokinetics and pharmacodynamics of thiopental / p35 (0042.jp2)
- 2.4. Pharmacokinetics and pharmacodynamics of oxazepam / p45 (0052.jp2)
- 2.5. Conclusion / p53 (0060.jp2)
- Chapter3 A possible mechanism for the enhanced sensitivity of thiopental in renal dysfunction:influence of plasma dialysate from normal and renal dysfunction rats on the EEG and GABAA receptor complex modulation / p54 (0061.jp2)
- 3.1. Introduction / p55 (0062.jp2)
- 3.2. Materials and methods / p55 (0062.jp2)
- 3.3. Results / p60 (0067.jp2)
- 3.4. Discussion / p70 (0077.jp2)
- 3.5. Conclusion / p73 (0080.jp2)
- Summary and General conclusions / p74 (0081.jp2)
- References / p78 (0085.jp2)
- List of publications from this thesis / p87 (0094.jp2)