Interaction and photocleavage of DNA with toxic metalloporphyrins of mercury(Ⅱ), lead(Ⅱ), and cadmium(Ⅱ) 水銀(Ⅱ),鉛(Ⅱ),およびカドミウム(Ⅱ)の毒性金属ポルフィリン錯体とDNAの相互作用とDNA光開裂反応
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Bibliographic Information
- Title
-
Interaction and photocleavage of DNA with toxic metalloporphyrins of mercury(Ⅱ), lead(Ⅱ), and cadmium(Ⅱ)
- Other Title
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水銀(Ⅱ),鉛(Ⅱ),およびカドミウム(Ⅱ)の毒性金属ポルフィリン錯体とDNAの相互作用とDNA光開裂反応
- Author
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Sarker, Ashish Kumar
- Author(Another name)
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サーカー, アシシュ クマール
- University
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佐賀大学
- Types of degree
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博士(理学)
- Grant ID
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甲第114号
- Degree year
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1999-03-31
Note and Description
博士論文
Table of Contents
- Contents/p1 (3コマ目)
- List of Figures/p3 (5コマ目)
- Abstract/p1 (8コマ目)
- Introduction/p3 (10コマ目)
- ChapterI Photocleavage of DNA with toxic metalloporphyrins/p17 (24コマ目)
- Experimental/p18 (25コマ目)
- Materials/p18 (25コマ目)
- Synthesis of metalloporphyrins/p18 (25コマ目)
- DNA cleavage experiment/p19 (26コマ目)
- Photoirradiation/p19 (26コマ目)
- Electrophoresis/p20 (27コマ目)
- Results/p21 (28コマ目)
- Irradiation time effect on metalloporphyrins mediated DNA cleavage/p21 (28コマ目)
- Visible light effect on the cleavage of DNA/p23 (30コマ目)
- Cleavage of DNA by metalloporphyrins in the dark/p23 (30コマ目)
- Comparison of DNA photocleavage by metalloporphyrins/p24 (31コマ目)
- Effect of metal ion concentration on DNA photocleavage in metalloporphyrins-DNA Mixture/p26 (33コマ目)
- Effect of porphyrin concentration on DNA photocleavage in metalloporphyrins-DNA Mixture/p28 (35コマ目)
- ChapterII Investigation of active species for DNA Photocleavage by scavengers and EPR technique/p30 (37コマ目)
- Experimental/p32 (39コマ目)
- DNA cleavage experiments with metalloporphyrins and reactive species scavengers/p32 (39コマ目)
- EPR spin-trapping experiments/p33 (40コマ目)
- Results/p34 (41コマ目)
- DNA cleavage experiment with scavengers/p34 (41コマ目)
- Identification of singlet oxygen (¹O₂) by EPR/p38 (45コマ目)
- Radicals identification by DMPO/p42 (49コマ目)
- Comparison of radical production using BPN/p46 (53コマ目)
- ChapterIII Interaction of toxic metalloporphyrins with DNA/p49 (56コマ目)
- Experimental/p50 (57コマ目)
- Materials/p50 (57コマ目)
- Methods/p50 (57コマ目)
- Instrumentation/p51 (58コマ目)
- Results/p52 (59コマ目)
- Electronic absorption spectra/p52 (59コマ目)
- Circular dichroism spectra/p55 (62コマ目)
- Fluorescence spectra/p59 (66コマ目)
- ChapterIV/p61 (68コマ目)
- Discussion/p62 (69コマ目)
- Conclusion/p70 (77コマ目)
- Acknowledgment/p71 (78コマ目)
- References/p72 (79コマ目)