Mechanisms of interleukin-6 synthesis by human rheumatoid synoviocytes 慢性関節リウマチ滑膜細胞のIL-6産生機序の解析
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著者
書誌事項
- タイトル
-
Mechanisms of interleukin-6 synthesis by human rheumatoid synoviocytes
- タイトル別名
-
慢性関節リウマチ滑膜細胞のIL-6産生機序の解析
- 著者名
-
宮澤, 敬治
- 著者別名
-
ミヤザワ, ケイジ
- 学位授与大学
-
東京大学
- 取得学位
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博士 (薬学)
- 学位授与番号
-
乙第14553号
- 学位授与年月日
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2000-02-09
注記・抄録
博士論文
目次
- Contents / p2 (0003.jp2)
- Preface / p4 (0005.jp2)
- Chapter1:Constitutive transcription of the human Interleukin-6 gene by rheumatoid synoviocytes:Spontaneous activation of NF-kB and CBF1 / p6 (0007.jp2)
- Abstract / p6 (0007.jp2)
- Introduction / p6 (0007.jp2)
- Materials and Methods / p7 (0008.jp2)
- Results / p12 (0013.jp2)
- Discussion / p16 (0017.jp2)
- Chapter2:Establishment and characterization of a novel human rheumatoid synoviocyte line,MH7A,immortalized with SV40 T antigen / p21 (0022.jp2)
- Abstract / p21 (0022.jp2)
- Introduction / p21 (0022.jp2)
- Materials and Methods / p22 (0023.jp2)
- Results / p28 (0029.jp2)
- Discussion / p31 (0032.jp2)
- Chapter3:Transcriptional roles of C/EBPβ, NF-kB, and C-promoter binding factor 1 in Interleukin-lβ-induced Interleukin-6 synthesis by human rheumatoid fibroblast-like synoviocytes / p36 (0037.jp2)
- Abstract / p36 (0037.jp2)
- Introduction / p36 (0037.jp2)
- Materials and Methods / p37 (0038.jp2)
- Results / p41 (0042.jp2)
- Discussion / p45 (0046.jp2)
- Chapter4:Regulation of Interleukin-1β-induced Interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase / p50 (0051.jp2)
- Abstract / p50 (0051.jp2)
- Introduction / p50 (0051.jp2)
- Materials and Methods / p51 (0052.jp2)
- Results / p56 (0057.jp2)
- Discussion / p59 (0060.jp2)
- Conclusion / p63 (0064.jp2)
- Acknowledgments / p64 (0065.jp2)
- References / p65 (0066.jp2)
- Figures and Tables / p77 (0078.jp2)