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Development of antiviral biomaterials by naturally occurring polysaccharides 天然多糖類による抗ウイルス性バイオ材料の開発

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著者

    • Tegshi Muschin トグシ ムスチン

書誌事項

タイトル

Development of antiviral biomaterials by naturally occurring polysaccharides

タイトル別名

天然多糖類による抗ウイルス性バイオ材料の開発

著者名

Tegshi Muschin

著者別名

トグシ ムスチン

学位授与大学

北見工業大学

取得学位

博士(工学)

学位授与番号

甲第111号

学位授与年月日

2011-09-09

注記・抄録

博士論文

To develop a biomaterial with an influenza virus-adsorptivefunctionality, an alkyl curdlan sulfate was prepared by ionic interactionbetween a positively charged didodecyldimethyl ammonium bromideand a negatively charged sulfate group of curdlan sulfate, which haspotent anti-HIV activity, and then coated on a membrane filter with a 1μmpore size by hydrophobic interaction with the long alkyl groups in thecurdlan sulfate. The alkyl curdlan sulfate with the degree of alkylation(DOA) of 0.03 (1 didodecyldimethyl group/12 sugar residues with 36hydroxyl or sulfate groups) showed potent anti-HIV activity in a 50%effective concentration (EC50) as low as 0.87 μg/ml (standard curdlansulfate EC50 = 0.3 μg/ml), and the activity decreased with increasing DOA.A DOA higher than 0.1 (1 didodecyldimethyl group/three sugar residueswith nine hydroxyl or sulfate groups) gave no anti-HIV activity. Althoughboth curdlan sulfate and alkyl curdlan sulfates did not inhibited infectionof MDCK cells by influenza viruses, the alkyl curdlan sulfate-coated

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各種コード

  • NII論文ID(NAID)
    500000564739
  • NII著者ID(NRID)
    • 8000000566978
  • 本文言語コード
    • eng
  • NDL書誌ID
    • 024071455
  • データ提供元
    • 機関リポジトリ
    • NDL-OPAC
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