Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma 口腔扁平上皮癌におけるmelanoma inhibitory activity 2 (MIA2)の腫瘍促進性

著者

    • Kurihara, Miyako
    • Kirita, Tadaaki
    • Sasahira, Tomonori
    • Ohmori, Hitoshi
    • Matsushima, Sayako
    • Yamamoto, Kazuhiko
    • Bosserhoff, Anja Katrin
    • Kuniyasu, Hiroki

書誌事項

タイトル

Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma

タイトル別名

口腔扁平上皮癌におけるmelanoma inhibitory activity 2 (MIA2)の腫瘍促進性

著者名

Kurihara, Miyako

著者名

Kirita, Tadaaki

著者名

Sasahira, Tomonori

著者名

Ohmori, Hitoshi

著者名

Matsushima, Sayako

著者名

Yamamoto, Kazuhiko

著者名

Bosserhoff, Anja Katrin

著者名

Kuniyasu, Hiroki

学位授与大学

奈良県立医科大学

取得学位

博士(医学)

学位授与番号

甲第605号

学位授与年月日

2013-04-16

注記・抄録

The role of melanoma inhibitory activity 2 (MIA2) was examined in human oral squamous cell carcinoma (OSCC). MIA2 expression was observed in 62 (66.7%) of 93 OSCCs and was associated with tumor expansion and nodal metastasis. MIA2 expression was inversely correlated with intratumoral infiltration of lymphocytes. MIA2 expression was found in 3 human OSCC lines. Invasion and anti-apoptotic survival were reduced by MIA2 knockdown in HSC3 cells. The number of MOLT-3 lymphocytes infiltrating the HSC3 cell layer was increased by MIA2 knockdown or MIA2 depletion by MIA2 knockdown and absorption with the antibody. In HSC3 cells, MIA2 knockdown decreased the expressions of vascular endothelial growth factor (VEGF), VEGF-C, VEGF-D. The downregulation of VEGF-C and -D was caused by inhibition of p38 and extracellular signal-regulated kinase (ERK)1/2, respectively. MIA2 was coprecipitated with integrin α4 andα5 in HSC3 cells. Integrin α4 knockdown decreased p38 phosphorylation and increased apoptosis, whereas integrin α5 knockdown decreased c-Jun N-terminal kinase (JNK) phosphorylation and apoptosis. Inhibition of JNK decreased apoptosis in the HSC3 cells. These findings suggest that the roles of MIA2 might be based on the variety of the integrins and the subtypes of mitogen-activated protein kinase.

博士(医学)・甲第605号・平成25年11月27日

開始ページ : 1460

終了ページ : 1469

PubMed番号 : http://www.ncbi.nlm.nih.gov/pubmed/23511560

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キーワード

各種コード

  • NII論文ID(NAID)
    500000731416
  • NII著者ID(NRID)
    • 8000000907288
    • 8000000907289
    • 8000000907290
    • 8000000907291
    • 8000000907292
    • 8000000907293
    • 8000000907294
    • 8000000907295
  • DOI
  • 本文言語コード
    • eng
  • データ提供元
    • 機関リポジトリ
    • NDLデジタルコレクション
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