Telithromycinの<I>in vitro</I>殺菌作用

• 新井 進

  アベンティスファーマ株式会社開発研究所薬理研究室

• 岡本 博樹

  アベンティスファーマ株式会社開発研究所薬理研究室

• 野口 恵子

  アベンティスファーマ株式会社開発研究所薬理研究室

• 牛場 薫

  アベンティスファーマ株式会社開発研究所薬理研究室

• 矢口 理史

  アベンティスファーマ株式会社開発研究所薬理研究室

書誌事項

タイトル別名

• <I>In vitro</I> bactericidal activity of telithromycin
• MBC/MIC ratio and killing curve
• MBC/MIC比と殺菌曲線

抄録

MBC/MIC ratio of telithromycin (TEL) for clinical isolates of Staphylococcus aureus (19 strains), Enterococcus faecalis (20 strains), Streptococcus pneumoniae (16 strains) and Haemophilus influenzae (18 isolates) in Japan was compared with those of erythromycin A (EM), clarithromycin (CAM), azithromycin (AZM) and josamycin (JM), existing macrolide antibiotics. As a result, MBC₅₀/MIC₅₀ and MBC₉₀/MIC₉₀ ratios of all compounds tested for S. aureus and E. faecalis were more than 32, but the ratios for S. pneumoniae and H. influenzae were less than 2. Therefore, this study suggested that TEL had bacteriostatic effects against S. aureus and E. faecalis, but bactericidal effect against S. pneumoniae and H. influenzae. In addition, the bactericidal activity of TEL against standard strains of S. aureus, S. pneumoniae and H. influenzae was compared with those of EM, CAM and AZM on the basis of their killing curves. Against S. aureus Smith, TEL was slightly less potent than CAM. However, as in the case of EM and AZM, TEL inhibited the proliferation at 1/2 MIC and showed mild bactericidal activity at MIC. Against S. pneumoniae DP-1, TEL inhibited the growth at the concentration lower than MIC and showed bactericidal activity at the MIC or concentration higher than MIC as observed in other reference drugs. Against H. influenzae ATCC 49247, TEL inhibited the growth at the 1/2 MIC and showed bactericidal activity at the concentration higher than MIC. TEL showed strong short-term bactericidal activity in comparison with EM, CAM and AZM, especially against S. pneumoniae DP-1 and H. influenzae ATCC 49247. Furthermore, marked regrowth as observed in S. aureus and H. influenzae ATCC 49247 in case of EM, CAM and AZM, was not observed in TEL.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 51 (Supplement1), 77-82, 2003

  公益社団法人 日本化学療法学会

キーワード

• MBC
• 殺菌力
• 殺菌曲線
• 殺菌作

詳細情報

• CRID: 1390001206290378880
• NII論文ID: 10012659304
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.51.supplement1_77
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2004050550
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可