Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp. I. Taxonomy, Fermentation and Biological Activity.

• NAKAO MASAFUMI

  Pharmacology Research laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

• MIYAGAWA KEN-ICHIRO

  Pharmaceutical Discovery Center, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

• NAKANO YOSHITAKA

  Pharmaceutical Discovery Center, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

• SAKANE TAKESHI

  Pharmaceutical Discovery Center, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

• TADA MAYUMI

  Pharmacology Research laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

• NISHIMURA OSAMU

  Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.

• FUJINO MASAHIKO

  Takeda Chemical Industries, Ltd.

書誌事項

タイトル別名

• I. Taxonomy, Fermentation and Biological Activity

抄録

Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A₁, A₂, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H, pylori infection as a single agent.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 54 (11), 926-933, 2001

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390282679127593472
• NII論文ID: 130003410397
• NII論文ID: 50001002023
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.54.926
• COI: 1:CAS:528:DC%2BD3MXovVOru7g%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 11827035
• Web Site: https://search.jamas.or.jp/link/ui/2002119612
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可