Genotype-Specific Association between Circulating Soluble Cellular Adhesion Molecules and Carotid Intima-Media Thickness in Community Residents: J-SHIPP Study
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- KOHARA Katsuhiko
- Department of Geriatric Medicine, Ehime University School of Medicine
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- TABARA Yasuharu
- Department of Geriatric Medicine, Ehime University School of Medicine
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- YAMAMOTO Yoshikuni
- Department of Geriatric Medicine, Ehime University School of Medicine
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- IGASE Michiya
- Department of Geriatric Medicine, Ehime University School of Medicine
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- NAKURA Jun
- Department of Geriatric Medicine, Ehime University School of Medicine
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- MIKI Tetsuro
- Department of Geriatric Medicine, Ehime University School of Medicine
書誌事項
- タイトル別名
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- <B>Genotype-Specific Association between Circulating Soluble Cellular Adhesion Molecules and Carotid Intima-Media Thickness in Community Residents: J-SHIPP Study</B>
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Plasma levels of soluble forms of cellular adhesion molecules (CAMs) and their relationships with carotid intima-media thickness (IMT) were investigated in community residents. Plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured by ELISA in 200 community residents in Japan. Carotid IMT showed a weak but significant positive correlation with the plasma levels of both sICAM-1 (r=0.175, p=0.013) and sVCAM-1 (r=0.19, p=0.0075). Gene polymorphisms of angiotensin converting enzyme (ACE) insertion⁄deletion (I⁄D), angiotensinogen (AGT) M235T, angiotensin II type 1 receptor (AT1R) A1166C and apolipoprotein E (apoE) were determined for each subject. The plasma level of sVCAM-1 tended to be lower in subjects with the ACE DD genotype than in those with the ACE ID and II genotypes (373±94, 421±133, 443±135 ng⁄ml, respectively, p=0.056). However, there were no genotype-specific differences in the plasma levels of soluble forms of CAMs for the other genes examined. In a separate analysis, the plasma level of sICAM-1 was significantly associated with carotid IMT in ACE D carriers (ID + DD) (r=0.28, p=0.002), AGT M carriers (MT + MM) (r=0.32, p=0.0045), and subjects with apoE4 (r=0.35, p=0.036). In contrast, the plasma level of sVCAM-1 showed significant positive correlations with carotid IMT in subjects with the ACE II genotype (r=0.33, p=0.0027) or AGT TT genotype (r=0.22, p=0.015), and subjects with apoE E2⁄E3 or E3⁄E3 (r=0.16, p=0.043). Stepwise regression analysis showed that plasma sVCAM-1 was independently associated with carotid IMT in subjects with the ACE II genotype or apoE4 genotype. Similarly, the plasma level of sICAM-1 was independently associated with carotid IMT in AGT M carriers. These findings suggest that genetic background could be involved in the association between plasma CAMs and atherosclerosis. (Hypertens Res 2002; 25: 31-39)
収録刊行物
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- Hypertension Research
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Hypertension Research 25 (1), 31-39, 2002
日本高血圧学会
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詳細情報
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- CRID
- 1390282679696839680
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- NII論文ID
- 130004436949
- 50001041943
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD38XislCksLs%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 11924723
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可