骨Ｐａｇｅｔ病の骨動態

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  • Bone Turn-over in Paget's Disease.

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Bone turn-over of Paget's disease was examined by biochemical and histomorphometric analysis in one female and two male patients, aged 72, 48 and 68, respectively.<br>All patients had polyostotic lesions involving the tibia, femur, pelvis, spine and skull. Elevations in serum alkaline phosphatase reflecting bone formation were demonstrated in all patients, and a high level of serum BGP was found in one patient. Increases in the urinary excretion of calcium and hydroxyproline were also noted, as a result of excessive bone resorption.<br>Histomorphometric data indicated that bone resorption and subsequent bone formation were highly excessive in Pagetic bone. Approximately 36% of bone surfaces were eroded, and 21% were osteoid in the 68-year-old male. In this specimen, the so-called mosaic pattern and woven bone pattern were also seen, reflecting rapid bone turn-over.<br>Calcitonin and etidronate disodium, or EHDP, were administered to each patient. EHDP was associated with a decrease in serum alkaline phosphatase levels, and urinary excretion of calcium and hydroxyproline, much as was observed with calcitonin.

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