書誌事項
- タイトル別名
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- Role of Viral Infections in Acute Exacerbation of Idiopathic Intersititial Pneumonia.
この論文をさがす
抄録
To evaluate the possibility that viral infections can trigger acute exacerbations of idiopathic interstitial penumonia (IIP), we analyzed data from 105 patients with IIP. Actue exacerbation was difined as an increase in dyspnea, a decrease in PaO2 by more than 10 Torr, and worsening of chest radiographic findings within one month. Viral infection was said to be involved when patients had more than a 4-fold change in viral antibody titer or viral inclusion bodies in sputum during the acute exacerbation. Of the 105 patients with IIP, 30 had acute xacerbations. Among these 30 patients, viral infection was said to be involved in 11 (37%). Presumptive viruses were influenza virus (n=6), parainfluenza virus (n=1), herpes simplex virus (n=1), RS virus (n=1), and cytomegalo virus (n=2). The levels of serum iminunoglobulin A (IgA) before acute exacerbations were significantly lower (P<0.05) in patients in whom viral infection was said to be involved. These results suggest that viral infection associated with a low value of serum IgA is an important trigger of acute exacerbations of IIP.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 33 (7), 723-727, 1995
社団法人 日本呼吸器学会