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- KIMURA Shigeru
- the Department of Internal Medicine , Nishijin Hospital
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- TANIGAWA Mari
- the Department of Internal Medicine , Nishijin Hospital
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- NAKAHASHI Yasumitsu
- the Department of Internal Medicine , Nishijin Hospital
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- INOUE Mamoru
- the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
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- YAMAMURA Yoshiharu
- the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
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- KATO Haruki
- the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
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- SUGINO Shigeru
- the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
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- KONDO Motoharu
- the First Department of Internal Medicine, Kyoto Prefectural University of Medicine
この論文をさがす
抄録
A 70-year-old man with Hashimoto's disease had selective IgM deficiency, while other immunoglobulin levels were normal. In vitro mixing experiments were carried out in which B cells and T cells from the patient and from a healthy control donor were co-cultured in the presence of pokeweed mitogen, in order to investigate the etiology of IgM hypoproduction. The results indicated that the patient had B-cell dysfunction, involving the impairment of B-cell differentiation. In addition, both IgG of the healthy control donor and thyroid hormone may play important roles in the pathogenesis of this case.<br>(Internal Medicine 32: 302-307, 1993)
収録刊行物
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- Internal Medicine
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Internal Medicine 32 (4), 302-307, 1993
一般社団法人 日本内科学会