The Cholinergic Hypothesis of Geriatric Memory Dysfunction

DOI Web Site 被引用文献82件
  • Raymond T. Bartus
    Department of CNS Research, Lederle Laboratories of American Cyanamid Co., Pearl River, New York 10965.
  • Reginald L. Dean
    Department of CNS Research, Lederle Laboratories of American Cyanamid Co., Pearl River, New York 10965.
  • Bernard Beer
    Department of CNS Research, Lederle Laboratories of American Cyanamid Co., Pearl River, New York 10965.
  • Arnold S. Lippa
    Department of CNS Research, Lederle Laboratories of American Cyanamid Co., Pearl River, New York 10965.

抄録

<jats:p>Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature. Significant cholinergic dysfunctions occur in the aged and demented central nervous system, relationships between these changes and loss of memory exist, similar memory deficits can be artificially induced by blocking cholinergic mechanisms in young subjects, and under certain tightly controlled conditions reliable memory improvements in aged subjects can be achieved after cholinergic stimulation. Conventional attempts to reduce memory impairments in clinical trials have not been therapeutically successful, however. Possible explanations for these disappointments are given and directions for future laboratory and clinical studies are suggested.</jats:p>

収録刊行物

  • Science

    Science 217 (4558), 408-414, 1982-07-30

    American Association for the Advancement of Science (AAAS)

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