Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

DOI Web Site 被引用文献24件
  • Robert Schwarcz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228
  • William O. Whetsell
    Division of Neuropathology, University of Tennessee School of Medicine, Memphis 38163
  • Richard M. Mangano
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228

抄録

<jats:p>A current hypothesis links the neuroexcitatory properties of certain acidic amino acids to their ability to cause selective neuronal lesions. Intracerebral injection of the neuroexcitatory tryptophan metabolite, quinolinic acid, has behavioral, neurochemical, and neuropathological consequences reminiscent of those of exogenous excitotoxins, such as kainic and ibotenic acids. Its qualities as a neurotoxic agent suggest that quinolinic acid should be considered as a possible pathogenic factor in neurodegenerative disorders.</jats:p>

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  • Science

    Science 219 (4582), 316-318, 1983-01-21

    American Association for the Advancement of Science (AAAS)

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