Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

• F. Barré-Sinoussi

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• J. C. Chermann

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• F. Rey

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• M. T. Nugeyre

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• S. Chamaret

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• J. Gruest

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• C. Dauguet

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• C. Axler-Blin

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

• F. Vézinet-Brun

  Hôpital Claude Bernard, Laboratoire Central-Virologie, 75019 Paris

• C. Rouzioux

  Hôpital Claude Bernard, Laboratoire Central-Virologie, 75019 Paris

• W. Rozenbaum

  Hôpital La Pitié-Salpétrière, Département de Santé Publique et Médecine Tropicale, 75013 Paris

• L. Montagnier

  Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15

抄録

A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus produced by these cells is similar to the original isolate. From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.

収録刊行物

• Science

  Science 220 (4599), 868-871, 1983-05-20

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1362262945411958784
• NII論文ID: 80001643115
• DOI: 10.1126/science.6189183
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.6189183
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