Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

• Norbert Kartner

  Ontario Cancer Institute, Princess Margaret Hospital, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M4X 1K9, Canada

• John R. Riordan

  Research Institute, Hospital for Sick Children, and Departments of Biochemistry and Clinical Biochemistry, University of Toronto, Toronto, Ontario, MSG 1X8

• Victor Ling

  Ontario Cancer Institute, Princess Margaret Hospital, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M4X 1K9, Canada

抄録

The plasma membranes of hamster, mouse, and human tumor cell lines that display multiple resistance to drugs were examined by gel electrophoresis and immunoblotting. In every case, increased expression of a 170,000-dalton surface antigen was found to be correlated with multidrug resistance. This membrane component is of identical molecular size and shares some immunogenic homology with the previously characterized P-glycoprotein of colchicine-resistant Chinese hamster ovary cells. This finding may have application to cancer therapy.

収録刊行物

• Science

  Science 221 (4617), 1285-1288, 1983-09-23

  American Association for the Advancement of Science (AAAS)

キーワード

• Multidisciplinary

詳細情報

• CRID: 1360574096457704192
• NII論文ID: 80001755070
• DOI: 10.1126/science.6137059
• ISSN: 10959203
• ISSN: 00368075
• ISSN: http://id.crossref.org/issn/00368075
• Web Site: https://www.science.org/doi/pdf/10.1126/science.6137059
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  • Crossref
  • CiNii Articles