ウサギにおけるコレステロール摂取およびたばこ煙吸入による実験的動脈硬化発生と末梢循環血液所見

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  • On Relationship between Biochemical and Hematological Measurements of Macrocirculatory Blood and Intravascular Behaviors of Cellular Components of Microcirculatory Blood in Dietary Induced Atherosclerosis in the Male Rabbit, with Special Regard to Influences of Cigarette Smoke Inhalation on It

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Normal male rabbits of which ear lobes had been installed a transparent round-table chamber for vital-microscopic observation of the cutaneous microcirculation were fed a cholesterol-supple-mented (1.5%, w/w) diet for a period of 12 weeks. A marked lipid accumulation in the wall of aorta was noticed at the end of the cholesterol loading during which an enormous elevation of LDL-cholesterol levels in plasma was observed concurrently with anemic findings on macrocirculatory blood and changes in intravascular behaviors of cellular components of microcirculatory blood. The anemic findings included decreases in erythrocyte counts, hematocrit values, and hemoglobin concentrations and increases in erythrocyte sedimentation rates as well as in carboxyhemoglobin concentrations. The intramicrovascular changes included enhancement of adhesiveness of circulating leukocytes showing thrombus-like formations on the wall of vessels and/or obstructions of vascular lumens and abnormal erythrocyte aggregation such as rouleau formation and sludging. Both the macrocirculatory and microcirculatory changes, in combination with the elevated LDL-cholesterol in blood, appeared to suggest to facilitate the atherogenic process through an increased permeability of the arterial endothelium resulted from the systemic anemia and local hypoxia due to the disturbance of oxygen supply of erythrocytes caused by the leukocyte adhesion to the wall of vessels. Although cigarette smoke inhalation alone (repeated two times a day in a dose of 5mm length of cigarette burnt for one smoking session) did not induce any appreciable changes in lipids in the aorta as well as in the biochemical measurements, during the same experimental period, inhalations of filtered (with glass fiber Cambridge filter) or non-filtered smoke concurrent with cholesterol feeding induced more or less alteration of the aortic accumulation of cholesterol and the macro- and microcirculatory findings on blood. Particularly the gase phase substances or carbon monoxide in cigarette smoke appeared to have exacerbating influences on the dietary atherogenic process.

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