ダイアライザーの性能評価における牛血液使用の問題点

DOI

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タイトル別名
  • Fitness of bovine blood for estimating dialyzer performance

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抄録

Frame the point of RBC membrane permeability the possibility of substituting bovine for human blood in estimating mass transfer resistance of a solute was investigated theoretically and experimentally. Urea transfer through both bovine and human RBC membrane is so rapid that conventional clearance could be used. Mass transfer resistance through bovine RBC membrane doesn't allow creatinine transfer easily. Creatinine can transfer slowly through human RBC membrane within the residence time passing through a dialyzer. This difference of permeability causes the disequilibrium between inside and outside of RBC on the venus side of a dialyzer and we overestimate creatinine clearance. This clearance should not be used for estimating the removed amount of a solute.

収録刊行物

  • 人工臓器

    人工臓器 13 (2), 664-667, 1984

    一般社団法人 日本人工臓器学会

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