書誌事項
- タイトル別名
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- Intravenous lidocaine in the treatment of convulsions in infancy.
- 新生児・乳児を中心に
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抄録
The anticonvulsant activity of lidocaine (Ld) was reported by Bernhard and Colleagues in 1955.<BR>It does not disturb the consciousness state, the effect is fast and it is maintainable with intravenous dripinfusion.<BR>Ld was tried in 12 cases of status epilepticus (SE) including 3 newborn infants, and in 4 cases of intractable seizures (IS), and the effect and the toxicity were evaluated clinically.<BR>Intravenous administration of Ld was stated in cases of SE with the initial dosis of 2mg/kg in 30 seconds, followed by continuous drip-infusion at the rate of 4mg/kg/hour.<BR>In cases of IS, drip-infusion (2mg/kg/hour) was continued until the oral anticonvulsants and/or the ketogenic diet became clinically effective.<BR>As a result of Ld treatment, SE was controlled in 11 cases out of 12, and 3 cases out of 4 of IS were kept in a non-convulsive state until seizures were controlled by therapy of the oral anticonvulsants and/or the ketogenic diet.<BR>Furthermore, it is noteworthy that all cases of neonatal convulsions were controlled by the Ld therapy.<BR>No abnormal changes were observed in pulse rate, blood pressure, ECG, liver function and renal function in any of these patients.<BR>It was concluded that Ld could be recommended as an excellent and non-toxic anticonvulsive agent in various convulsive disorders.
収録刊行物
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- 脳と発達
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脳と発達 17 (3), 203-209, 1985
THE JAPANESE SOCIETY OF CHILD NEUROLOGY
