パラチノース蜜の齲蝕誘発能

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  • Caries-inducing Activity of Palatinose Syrup

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The caries-inducing activity of palatinose syrup was assessed in vitro and in SPF rats. The syrup is a mixture of mono- and loigo-saccharides and composed of trehalurose and palatinose as the principle constituents. Streptococcus mutans MT8148R (serotype c) and 6715 (serotype g) were able to ferment the palatinose syrup and the pH of the culture decreased markedly. Growing cells of S. mutans MT8148R and 6715 producted a marked adherence to a glass surface in 1% sucrose. However, the percent of adherence decreased when the same amount of palatinose syrup was added to the reaction mixture.<BR>Crude GTase prepared from each strain synthesized insoluble glucan from sucrose. However, the amount of insoluble glucan produced from sucrose by GTase decreased makedly when increasing amounts of palatinose syrup were added to the reaction mixture containing 1% sucrose.<BR>The caries-inducing potential of palatinose syrup was examined using SPF SD rats which had been infected with S. mutans MT8148R or 6715 and fed a cariesinducing diet#2000 containing 56% sucrose, in which palatinose syrup replaced the sucrose fraction. Palatinose syrup did develop weak caries, whereas sucrose manifested significant dental caries in the rats.<BR>However, the caries score of palatinose-syrup-fed rats was significantly higher than that of the wheat flour-fed rats. Furtheremore, partial replacement of the sucrose content with palatinose syrup did not result in a significant reduction of caries development.<BR>These results suggest that the cariogenicity of palatinose syrup may be low, and the cariostatic effect may be extremely weak even if it is recognized.

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