Papillomavirus DNA in human tongue carcinomas

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Abstract

<jats:title>Abstract</jats:title><jats:p>Seven biopsies from different carcinomas of the tongue were analyzed for human papilloma virus (HPV) sequences by Southern blot analysis. After hybridization with various types of human papilloma viruses, 1 tumors were found to be positive. Whereas DNA from one tumor hybridized with HPY 2 DNA under conditions of high stringency, the 2 other positive biopsies contained HPV 16 DNA. All positive tumors revealed high copy numbers of the respective DNA. The cleavage pattern of the HPV‐2‐positive tumor differed from the established HPV 2 prototypes. Minor differences from the HPV 16 prototype were also noted in one of the HPV‐16‐positive tongue carcinomas.</jats:p>

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