老年者の大動脈脈波速度に関する研究

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タイトル別名
  • Pulse Wave Velocity in the Eldely

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A total of 336 subjects entered the study. Pulse wave velocity (PWV) was measured above 60 years (77.0±6.6 mean±SD, 145 men and 191 women). PWV gradually increased with age (r=0.29, p<0.01). In man mean ±SD PWV of normotensive 60-69 years, 70-79 years, and 80-89 years were 8.95±2.32m/sec (n=20), 10.27±2.11 m/sec (n=33) and 11.35±2.54m/sec (n=19) respectively. Hypertensive men showed higher but not significant PWV and their agewise increase was less than in normotensive men. Mean PWV±SD of normotensive women in sixties, seventies and eighties were 8.37±1.75 (n=16), 10.03±1.65 (n=38), 10.64±2.88 (n=28) m/sec respectively. Again those of hypertensive women were generally higher than of normotensive women but with less agewise increase. Total cholesterol and HDL cholesterol were not significantly correlated with PWV (r=0.06, -0.09), whereas LDL cholesterol was significantly correlated with PWV (r=0.11, p<0.05). HDL/LDL ratio showed significant negative correlation (r=-0.12, p<0.05), and low HDL/LDL ratio was significantly frequently observed in high PWV individual over. 15m/sec. Systolic blood pressure showed most positive significant correlation with PWV (r=0.30, p<0.01). Diastolic pressure was not significantly correlated. The results confirm the agewise increase of PWV and the accelerating influence of hypertension with less agewise effect and moderate correlation with LDL cholesterol.

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