Molecular Genetics of Human Color Vision: The Genes Encoding Blue, Green, and Red Pigments

DOI Web Site 被引用文献78件
  • Jeremy Nathans
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
  • Darcy Thomas
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
  • David S. Hogness
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.

抄録

<jats:p>Human color vision is based on three light-sensitive pigments. The isolation and sequencing of genomic and complementary DNA clones that encode the apoproteins of these three pigments are described. The deduced amino acid sequences show 41 ± 1 percent identity with rhodopsin. The red and green pigments show 96 percent mutual identity but only 43 percent identity with the blue pigment. Green pigment genes vary in number among color-normal individuals and, together with a single red pigment gene, are proposed to reside in a head-to-tail tandem array within the X chromosome.</jats:p>

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  • Science

    Science 232 (4747), 193-202, 1986-04-11

    American Association for the Advancement of Science (AAAS)

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